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The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review

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收录情况： ◇ SCIE

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机构： [1]School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [2]Department of Oncology, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, China. [3]Department of Interventional Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.

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关键词： apoptosis cancer progression CDC20 CDC20-target inhibitors tumorigenesis

摘要：

The cell division cycle 20 homologue (CDC20) is known to regulate the cell cycle. Many studies have suggested that dysregulation of CDC20 is associated with various pathological processes in malignant solid tumors, including tumorigenesis, progression, chemoradiotherapy resistance, and poor prognosis, providing a biomarker for cancer diagnosis and prognosis. Some researchers have demonstrated that CDC20 also regulates apoptosis, immune microenvironment, and tumor angiogenesis. In this review, we have systematically summarized the biological functions of CDC20 in solid cancers. Furthermore, we briefly synthesized multiple medicines that inhibited CDC20. We anticipate that CDC20 will be a promising and effective biomarker and therapeutic target for the treatment of human cancer.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：内科

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出版当年[2023]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q2 MEDICINE, GENERAL & INTERNAL

影响因子： 1.4 最新[2023版] 1.6 最新五年平均 1.4 出版当年[2023版] 1.6 出版当年五年平均 1.6 出版前一年[2022版]

第一作者：

第一作者机构： [1]School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [2]Department of Oncology, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, China.

通讯作者：

通讯机构： [3]Department of Interventional Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. [*1]Department of Interventional Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 611731, China

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The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review

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