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Fecal Microbiota Transplantation-Mediated Ghrelin Restoration Improves Neurological Functions After Traumatic Brain Injury: Evidence from 16S rRNA Sequencing and In Vivo Studies

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机构： [1]Key Laboratory of Clinical Genetics, Afliated Hospital of Chengdu University, No. 82, North Section 2, 2nd Ring Road, Chengdu 610081, People’s Republic of China [2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China [3]Department of Radiation Protection Medicine, Faculty of Preventive Medicine, Air Force Medical University, Xi’an 710032, People’s Republic of China [4]Department of Neurology, Afliated Hospital of Chengdu University, Chengdu 610082, People’s Republic of China [5]Institute of Blood Transfusion, Chinese Academy of Medical Sciences, No. 76, Huacai Road, Chenghua District, Chengdu 610052, Sichuan Province, People’s Republic of China

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关键词： 16S rRNA sequencing Traumatic brain injury Gut microbiota Brain-gut axis Blood-brain barrier disruption Neurological injury Ghrelin TNF-α pathway

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This study aimed to investigate how gut microbiota dysbiosis impacts the repair of the blood-brain barrier and neurological deficits following traumatic brain injury (TBI). Through 16S rRNA sequencing analysis, we compared the gut microbiota of TBI rats and normal controls, discovering significant differences in abundance, species composition, and ecological function, potentially linked to Ghrelin-mediated brain-gut axis functionality. Further, in vivo experiments showed that fecal microbiota transplantation or Ghrelin injection could block the intracerebral TNF signaling pathway, enhance GLP-1 expression, significantly reduce brain edema post-TBI, promote the repair of the blood-brain barrier, and improve neurological deficits. However, the TNF signaling pathway activation could reverse these beneficial effects. In summary, our research suggests that by restoring the balance of gut microbiota, the levels of Ghrelin can be elevated, leading to the blockade of intracerebral TNF signaling pathway and enhanced GLP-1 expression, thereby mitigating post-TBI blood-brain barrier disruption and neurological injuries.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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大类 | 2 区医学

小类 | 2 区神经科学

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大类 | 2 区医学

小类 | 2 区神经科学

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第一作者机构： [1]Key Laboratory of Clinical Genetics, Afliated Hospital of Chengdu University, No. 82, North Section 2, 2nd Ring Road, Chengdu 610081, People’s Republic of China

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