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Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

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机构: [1]Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China [3]Sichuan Hua Xi Kindstar Medical Diagnostic Centre, Chengdu, Sichuan, China [4]Sichuan neo-life stem cell biotech inc., Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China [5]Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
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Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. While STRN3-RARA leukemia quickly relapses after ATRA treatment, they can be restrained by cepharanthine.Copyright © 2023 American Society of Hematology.

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出版当年[2023]版:
大类 | 1 区 医学
小类 | 1 区 血液学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 血液学
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第一作者机构: [1]Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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