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Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma

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收录情况: ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越:领军期刊

机构: [1]Department of AnalyticalChemistry, State KeyLaboratory of Drug Researchand CAS Key Laboratory ofReceptor Research,Shanghai Institute ofMateria Medica, ChineseAcademy of Sciences,Shanghai 201203, China [2]Department of LiverSurgery and Transplantation,Liver Cancer Institute,Zhongshan Hospital, and KeyLaboratory of Carcinogenesisand Cancer Invasion ofMinistry of Education, FudanUniversity, Shanghai200032, China [3]School ofChinese Materia Medica,Nanjing University ofChinese Medicine, Nanjing210023, China [4]Institutesfor Systems Genetics andNHC Key Lab of TransplantEngineering andImmunology, SichuanProvincial EngineeringLaboratory of Pathology inClinical Application, WestChina Hospital, SichuanUniversity, Chengdu 610041,China [5]University ofChinese Academy ofSciences, Beijing 100049,China [6]Department ofMedicine, McDonnellGenome Institute, SitemanCancer Center, WashingtonUniversity, St. Louis, MI63108, USA [7]Department ofGenetics and GenomicSciences, Icahn School ofMedicine at Mount Sinai,NewYork, NY 10029, USA [8]Lester and Sue SmithBreast Center, Department ofMolecular and HumanGenetics, Baylor College ofMedicine, One Baylor Plaza,Houston, TX 77030, USA [9]State Key Laboratory of CellBiology, CAS Center forExcellence in Molecular CellScience, Shanghai Instituteof Biochemistry and CellBiology, Chinese Academy ofSciences, Shanghai 200031,China
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关键词: proteomics hepatocellular carcinoma normal tissue adjacent to tumor heterogeneity

摘要:
Normal adjacent tissues (NATs) of hepatocellular carcinoma (HCC) differ from healthy liver tissues and their heterogeneity may contain biological information associated with disease occurrence and clinical outcome that has yet to be fully evaluated at the proteomic level. This study provides a detailed description of the heterogeneity of NATs and the differences between NATs and healthy livers and revealed that molecular features of tumor subgroups in HCC were partially reflected in their respective NATs. Proteomic data classified HCC NATs into two subtypes (Subtypes 1 and 2), and Subtype 2 was associated with poor prognosis and high-risk recurrence. The pathway and immune features of these two subtypes were characterized. Proteomic differences between the two NAT subtypes and healthy liver tissues were further investigated using data-independent acquisition mass spectrometry, revealing the early molecular alterations associated with the progression from healthy livers to NATs. This study provides a high-quality resource for HCC researchers and clinicians and may significantly expand the knowledge of tumor NATs to eventually benefit clinical practice.© The Author(s) 2023. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

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出版当年[2023]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2023]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
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第一作者机构: [1]Department of AnalyticalChemistry, State KeyLaboratory of Drug Researchand CAS Key Laboratory ofReceptor Research,Shanghai Institute ofMateria Medica, ChineseAcademy of Sciences,Shanghai 201203, China
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通讯机构: [1]Department of AnalyticalChemistry, State KeyLaboratory of Drug Researchand CAS Key Laboratory ofReceptor Research,Shanghai Institute ofMateria Medica, ChineseAcademy of Sciences,Shanghai 201203, China [3]School ofChinese Materia Medica,Nanjing University ofChinese Medicine, Nanjing210023, China [5]University ofChinese Academy ofSciences, Beijing 100049,China
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