详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Hypoxia-responsive lncRNA G077640 promotes ESCC tumorigenesis via the H2AX-HIF1α-glycolysis axis

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Department of Gastroenterology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China. [3]Department of Cardiothoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [4]Key Laboratory of Medical Electrophysiology of the Ministry of Education, and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China. [5]Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

出处：

DOI：

ISSN：

摘要：

Long noncoding RNAs (lncRNAs) contribute to esophageal squamous cell carcinoma (ESCC) progression, but the underlying mechanisms remain elusive. In this study, we verified a hitherto uncharacterized hypoxia-responsive lncRNA, G077640, which is upregulated in human ESCC cells and tissues, supporting the proliferation and migration of ESCC cells. Mechanistically, G077640 prevented hypoxia-inducible factor-1α (HIF1α) from being degraded by directly interacting with histone H2AX and further modulated the interaction of HIF1α and H2AX. In addition, G077640 reprogrammed glycolytic metabolism by regulating the expression of glucose transporter 4 (GLUT4), hexokinase 2 (HK2) and pyruvate dehydrogenase kinase 1 (PDK1) for ESCC proliferation and migration. Clinically, G077640 was associated with poor prognosis in ESCC patients. Taken together, our findings identified a hypoxia-responsive lncRNA that contributes to ESCC cells proliferation and migration, and targeting G077640 and its pathway might be a potential therapeutic strategy for ESCC.© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Department of Gastroenterology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [*1]No 5, Taiping street, Jiangyang District,Luzhou City, Sichuan Province 646000, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：