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PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

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机构: [1]Institute of Precision Cancer Medicine and Pathology, And Department of Pathology, School of Medicine, And Minister of Education Key Laboratory of Tumor Molecular [2]Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China [3]Cancer Research Center, Shantou University Medical College, Shantou, Guangdong, China [4]Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, China [5]Department of Urology Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China [6]Department of Oncology, People’s Hospital of Leshan, Leshan, Sichuan, China [7]Health Care Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China [8]Department of Pathology, Gongli Hospital, Naval Medical University, Shanghai, China [9]Department of Pathology, Heping Hospital, Changzhi Medical College, Changzhi, Shanxi, China [10]Department of Thoracic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China [11]Department of General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China [12]Department of Central Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China [13]Department of Clinical Laboratory, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People’s Hospital), Heyuan, Guangdong, China [14]Department of Urology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China [15]MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, Jiangsu, China [16]Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA [17]College of Clinical Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Henan Key Laboratory of Cancer Epigenetics, Luoyang, [18]Department of Emergency Medicine, University of Texas MD Anderson Cancer Center and Department of Endocrine Neoplasia and Hormonal Disorders, University of
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关键词: PTPRO Tyrosine phosphatase MET Esophageal squamous cell carcinoma Metastasis

摘要:
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPROlow/p-METhigh had significantly poor prognosis, suggesting that PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.Copyright © 2023 Elsevier B.V. All rights reserved.

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出版当年[2023]版:
大类 | 1 区 医学
小类 | 2 区 肿瘤学
最新[2023]版:
大类 | 1 区 医学
小类 | 2 区 肿瘤学
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Q1 ONCOLOGY
最新[2023]版:
Q1 ONCOLOGY

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第一作者机构: [1]Institute of Precision Cancer Medicine and Pathology, And Department of Pathology, School of Medicine, And Minister of Education Key Laboratory of Tumor Molecular [2]Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China
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通讯机构: [2]Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China [17]College of Clinical Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Henan Key Laboratory of Cancer Epigenetics, Luoyang, [18]Department of Emergency Medicine, University of Texas MD Anderson Cancer Center and Department of Endocrine Neoplasia and Hormonal Disorders, University of [*1]Department of General Surgery, The First Affliated Hospital of Jinan University, 613 Huangpu Avenue West, Guangzhou, Guangdong, 510630,China. [*2]College of Clinical Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Henan Key Laboratory of Cancer Epigenetics, Luoyang, 471000, Henan, China. [*3]Department of Emergency Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
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