机构：[1]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.[2]State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China.[3]Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.[4]Department of Orthopaedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical University, 210006, Nanjing, China.[5]Jinhua Institute of Zhejiang University, Jinhua 321299, China.[6]Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.[7]National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China.
Intratissue topical medication is important for the treatment of cutaneous, mucosal or splanchnic diseases. However, penetrating surface barriers to providing adequate and controllable drug delivery while guaranteeing adhesion in bodily fluids remains challenging. Here, the predatory behavior of the blue-ringed octopus inspired us with a strategy to improve topical medication. For effective intratissue drug delivery, the active injection microneedles were prepared in a manner inspired by the teeth and venom secretion of blue-ringed octopus. With on demand release function guided by temperature-sensitive hydrophobic and shrinkage variations, these microneedles can supply adequate drug delivery at an early stage and then achieve the long-term release stage. Meanwhile, the bionic suction cups were developed to facilitate microneedles to stay firmly in place (>10 kilopascal) when wet. With wet bonding ability and multiple delivery mode, this microneedle patch achieved satisfactory efficacy, such as accelerating the ulcers' healing speed or halting early tumor progression.
基金：
National Key Research and Development Program of China 2018YFA0703000 (to Y.H.), Science
Fund for Creative Research Groups of the National Natural Science Foundation of China
T2121004 (to Y.H.), National Natural Science Foundation of China 52235007 (to Y.H.), National
Natural Science Foundation of China 82101076 (to Z.Z.), Research Funding from West China
School/Hospital of Stomatology Sichuan University RCDWJS2021-7 (to Z.Z.), and Research and
Develop Program from West China School/Hospital of Stomatology Sichuan University RD-02-
202109 (Z.Z.).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|1 区综合性期刊
小类|1 区综合性期刊
最新[2023]版：
大类|1 区综合性期刊
小类|1 区综合性期刊
第一作者：
第一作者机构：[1]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.[2]State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China.
共同第一作者：
通讯作者：
通讯机构：[3]Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.[5]Jinhua Institute of Zhejiang University, Jinhua 321299, China.[6]Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.[7]National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China.
推荐引用方式(GB/T 7714)：
Zhu Zhou,Wang Jian,Pei Xibo,et al.Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery[J].Science advances.2023,9(25):eadh2213.doi:10.1126/sciadv.adh2213.
APA：
Zhu Zhou,Wang Jian,Pei Xibo,Chen Junyu,Wei Xinwei...&He Yong.(2023).Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery.Science advances,9,(25)
MLA：
Zhu Zhou,et al."Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery".Science advances 9..25(2023):eadh2213
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