机构：[1]West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[3]Department of General Surgery, Nanchang First Hospital, Nanchang University, Nanchang, Jiangxi, China.
Increasing evidence indicates that obesity is a risk factor for various tumors. We aimed to clarify the evidence for an association between body mass index (BMI) and cancer risk based on existing systematic reviews and meta-analyses. Eighteen studies were included in this umbrella review after searching PubMed, Embase and Web of science. The results revealed that underweight was inversely associated with the incidence of brain tumors and positively related to the risk of esophageal and lung cancer. Overweight enhances the incidence of brain tumors, kidney cancer, endometrial cancer, ovarian cancer, multiple myeloma, bladder cancer and liver cancer. Obesity was related to the increased incidence of brain tumors, cervical cancer, kidney cancer, endometrial cancer, esophageal cancer, gastric cancer, ovarian cancer, multiple myeloma, gallbladder cancer, bladder cancer, colorectal cancer, liver cancer, thyroid cancer and Hodgkin's lymphoma. Moreover, dose-response analysis was conducted by 10 studies, and the results demonstrated that each 5 Kg/m2 increase in BMI was associated with a 1.01- to 1.13-fold increased risk of general brain tumors, multiple myeloma, bladder cancer, pancreatic cancer, breast cancer, and non-Hodgkin's lymphoma. Every 1 Kg/m2 increase in BMI was linked to 6% and 4% increases in the risk of kidney cancer and gallbladder cancer, respectively.
基金：
This work was supported by the Project of Science and
Technology Department of Sichuan Province (Grant ID:
2021YFS0117).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|4 区医学
小类|4 区营养学4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区营养学4 区肿瘤学
第一作者：
第一作者机构：[1]West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.[2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.[*1]Department of Urology, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, Sichuan 610041, P.R. China.
推荐引用方式(GB/T 7714)：
Chen Junhao,Ke Kaimin,Liu Zhenghuan,et al.Body Mass Index and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies[J].Nutrition and cancer.2023,75(4):1051-1064.doi:10.1080/01635581.2023.2180824.
APA：
Chen Junhao,Ke Kaimin,Liu Zhenghuan,Yang Luchen,Wang Linchun...&Dong Qiang.(2023).Body Mass Index and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies.Nutrition and cancer,75,(4)
MLA：
Chen Junhao,et al."Body Mass Index and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies".Nutrition and cancer 75..4(2023):1051-1064
