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High quality diet attenuated the positive association between polychlorinated biphenyls and premature mortality among middle-aged and older adults

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资源类型：
Pubmed体系：
作者：
Ni Weigui[1,2,3] ; Xue Qingping[4] ; Zhang Shanshan[1,2,3] ; Yang Xue[1,2,3] ; Wu Shiyi[1,2,3] ; He Xingcheng[1,2] ; Xiao Yan[1,2,3] ; Chang Wenling[3] ; Wen Ying[5] ; Huang Yichao[6] ; Wang Yi-Xin[7] ; Chen Da[8] ; Yang Chun-Xia[3,*2] ; Pan Xiong-Fei[1,2,*1] ;
机构： [1]Section of Epidemiology and Population Health, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation, West China Second University Hospital, Sichuan University [2]Shuangliu Institute of Women’s and Children’s Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China [3]Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China [4]Department of Epidemiology and Biostatistics, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China [5]Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China [6]Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, China [7]Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA [8]School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong, China
出处：
DOI： 10.1016/j.envres.2023.116031
ISSN：

摘要：
Polychlorinated biphenyls (PCBs) have been reported to be a risk factor for premature death, while a high diet quality is thought to lower mortality risk. We aimed to examine whether PCBs were associated with higher all-cause and cause-specific mortality risk and whether such associations could be modified by the diet quality among US middle-aged and older adults.Included were 1259 participants aged 40 years or older from the 1999-2004 National Health and Nutrition Examination surveys. Exposure to PCBs was assessed in non-fasting serum samples, and mortality status was ascertained through December 31, 2019 using the public-use, linked mortality files. Diet quality was assessed using the Healthy Eating Index-2015 based on 24-h dietary recalls. Cox proportional hazard regression was applied to assess the associations of different PCB congener groups with mortality and the modifying effect by the diet quality.During a median follow-up of 17.75 years, 419 deaths occurred, including 131 from cardiovascular disease (CVD) and 102 from cancer. Serum concentrations of dioxin-like PCBs and non-dioxin-like PCBs were significantly associated with all-cause mortality, with hazard ratios (HRs) of 1.84 (95% confidence interval [CI], 1.10, 2.99) and 1.82 (1.09, 3.03) for extreme-tertile comparisons. A significant interaction was noted between dioxin-like PCBs and diet quality (P for interaction: 0.012), with a substantially more pronounced association among participants with a low diet quality (HR, 3.47; 95% CI: 1.29, 9.32), compared to those with a high diet quality (HR, 0.98; 95% CI: 0.40, 2.43). A similar weaker association was observed for total PCBs in participants with a high diet quality (P for interaction: 0.032). However, effect modifications by diet quality were not noted for the associations between different PCB groups and CVD mortality.While our findings need to be validated in other populations and mechanistic studies, they may suggest that a high quality diet could potentially attenuate the harmful effects of chronic PCB exposure.Copyright © 2023 Elsevier Inc. All rights reserved.

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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 环境科学与生态学
小类 | 1 区 公共卫生、环境卫生与职业卫生 2 区 环境科学
最新[2023]版：
大类 | 2 区 环境科学与生态学
小类 | 1 区 公共卫生、环境卫生与职业卫生 2 区 环境科学
第一作者：
第一作者机构： [1]Section of Epidemiology and Population Health, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation, West China Second University Hospital, Sichuan University [2]Shuangliu Institute of Women’s and Children’s Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China [3]Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
通讯作者：
通讯机构： [1]Section of Epidemiology and Population Health, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation, West China Second University Hospital, Sichuan University [2]Shuangliu Institute of Women’s and Children’s Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China [3]Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China [*1]West China Second University Hospital, Sichuan University, No. 17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China. [*2]West China School of Public Health, Sichuan University, No. 17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China
推荐引用方式(GB/T 7714)：
Ni Weigui,Xue Qingping,Zhang Shanshan,et al.High quality diet attenuated the positive association between polychlorinated biphenyls and premature mortality among middle-aged and older adults[J].Environmental research.2023,231(Pt 2):116031.doi:10.1016/j.envres.2023.116031.
APA：
Ni Weigui,Xue Qingping,Zhang Shanshan,Yang Xue,Wu Shiyi...&Pan Xiong-Fei.(2023).High quality diet attenuated the positive association between polychlorinated biphenyls and premature mortality among middle-aged and older adults.Environmental research,231,(Pt 2)
MLA：
Ni Weigui,et al."High quality diet attenuated the positive association between polychlorinated biphenyls and premature mortality among middle-aged and older adults".Environmental research 231..Pt 2(2023):116031

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