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Enhancing the anti-tumor response by combining DNA damage repair inhibitors in the treatment of solid tumors

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机构： [1]Lung Cancer Institute/Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, People’s Republic of China [2]Department of Gastrointestinal Surgery, Chengdu Second People’s Hospital, No. 10 Qinyun Nan Street, Chengdu 610041, Sichuan Province, People’s Republic of China

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The anti-cancer efficacy of anti-malignancy therapies is related to DNA damage. However, DNA damage-response mechanisms can repair DNA damage, failing anti-tumor therapy. The resistance to chemotherapy, radiotherapy, and immunotherapy remains a clinical challenge. Thus, new strategies to overcome these therapeutic resistance mechanisms are needed. DNA damage repair inhibitors (DDRis) continue to be investigated, with polyadenosine diphosphate ribose polymerase inhibitors being the most studied inhibitors. Evidence of their clinical benefits and therapeutic potential in preclinical studies is growing. In addition to their potential as a monotherapy, DDRis may play an important synergistic role with other anti-cancer therapies or in reversing acquired treatment resistance. Here we review the impact of DDRis on solid tumors and the potential value of combinations of different treatment modalities with DDRis for solid tumors.Copyright © 2023. Published by Elsevier B.V.

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出版当年[2023]版中科院分区表Review为是的期刊

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大类 | 1 区

医学

小类 | 2 区生化与分子生物学 2 区生物物理 2 区肿瘤学

最新[2023]版

：

大类 | 1 区

医学

小类 | 2 区生化与分子生物学 2 区生物物理 2 区肿瘤学

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第一作者机构： [1]Lung Cancer Institute/Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, People’s Republic of China [2]Department of Gastrointestinal Surgery, Chengdu Second People’s Hospital, No. 10 Qinyun Nan Street, Chengdu 610041, Sichuan Province, People’s Republic of China

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