机构：[1]Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.[2]Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China.[3]Department of Nuclear Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Cyclin-Dependent Kinase Inhibitor 2A/B (CDKN2A/B) homozygous deletion was a significant prognostic factor for gliomas and affected the treatment strategy. However, the radiomic features of CDKN2A/B homozygous deletion in gliomas have not been developed, and whether the radiomic features and molecular subgroups can provide prognostic value in low-grade gliomas (LGGs) has yet to be studied. Thus, this study aimed to develop a predictive model of CDKN2A/B in gliomas and investigate the prognostic value of this biomarker and radiomic features in isocitrate dehydrogenase (IDH)-mutant LGGs. First, we developed the predictive model of CDKN2A/B homozygous deletion in 292 patients. The results revealed that radiomic features predict CDKN2A/B homozygous deletion with high accuracy and reliability. Subsequently, the prognostic survival models of 104 patients (IDH-mutant LGGs) were established, which provided an essential value for prognostic evaluation and indicated that CDKN2A/B homozygous deletion can be used as an independent predictor of prognosis in LGGs.
基金：
This work was supported by Sichuan Science and Technology Program (2023YFQ0002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|3 区神经科学
最新[2023]版：
大类|3 区医学
小类|3 区神经科学
第一作者：
第一作者机构：[1]Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Jing,Li Lei,Luo Tao,et al.Cyclin-Dependent Kinase Inhibitor 2A/B Homozygous Deletion Prediction and Survival Analysis[J].Brain sciences.2023,13(4):doi:10.3390/brainsci13040548.
APA：
Yang Jing,Li Lei,Luo Tao,Nie Chengsong,Fan Rui...&Chen Wei.(2023).Cyclin-Dependent Kinase Inhibitor 2A/B Homozygous Deletion Prediction and Survival Analysis.Brain sciences,13,(4)
MLA：
Yang Jing,et al."Cyclin-Dependent Kinase Inhibitor 2A/B Homozygous Deletion Prediction and Survival Analysis".Brain sciences 13..4(2023)
