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Bioinspired Tumor-Targeting and Biomarker-Activatable Cell-Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization

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资源类型：
Pubmed体系：
作者：
Yang Xiao[1,2,3,4] * ; Gao Simin[5] * ; Yang Boguang[1] * ; Yang Zhinan[1] ; Lou Feng[6] ; Huang Pei[7] ; Zhao Pengchao[1] ; Guo Jiaxin[8] ; Fang Huapan[9] ; Chu Bingyang[10] ; He Miaomiao[11] ; Wang Ning[12] ; Chan Anthony Hei Long[3] ; Chan Raymond Hon Fu[3] ; Wang Zuankai[2,3,4,13] ; Bian Liming[14,15] ; Zhang Kunyu[14,15] ;
机构： [1]Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, 999077, China. [2]Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China. [3]Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Shatin, Hong Kong, 999077, China. [4]Department of Mechanical Engineering, City University of Hong Kong, Kowloon, Hong Kong, 999077, China. [5]Department of Otorhinolaryngology and Sleep Medicine Center, West China School of Public Health and West China Forth Hospital, Sichuan University, Chengdu, 610065, China. [6]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. [7]School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China. [8]Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, 999077, China. [9]Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China. [10]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610065, China. [11]Analytical and Testing Center, Sichuan University, Chengdu, 610065, China. [12]College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. [13]Centre for Nature-Inspired Engineering, City University of Hong Kong, Kowloon, Hong Kong, 999077, China. [14]School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China. [15]National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China.
出处：
DOI： 10.1002/advs.202302272

摘要：
Osteosarcoma is an aggressive malignant tumor that primarily develops in children and adolescents. The conventional treatments for osteosarcoma often exert negative effects on normal cells, and chemotherapeutic drugs, such as platinum, can lead to multidrug resistance in tumor cells. Herein, this work reports a new bioinspired tumor-targeting and enzyme-activatable cell-material interface system based on DDDEEK-pY-phenylboronic acid (SAP-pY-PBA) conjugates. Using this tandem-activation system, this work selectively regulates the alkaline phosphatase (ALP) triggered anchoring and aggregation of SAP-pY-PBA conjugates on the cancer cell surface and the subsequent formation of the supramolecular hydrogel. This hydrogel layer can efficiently kill osteosarcoma cells by enriching calcium ions from tumor cells and forming a dense hydroxyapatite layer. Owing to the novel antitumor mechanism, this strategy neither hurts normal cells nor causes multidrug resistance in tumor cells, thereby showing an enhanced tumor treatment effect than the classical antitumor drug, doxorubicin (DOX). The outcome of this research demonstrates a new antitumor strategy based on a bioinspired enzyme-responsive biointerface combining supramolecular hydrogels with biomineralization.© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

基金：
This work was supported by InnoHK Project on [Project 1.2 – Novel Drug Delivery Systems to Achieve Precision Medicine for Acute CVD Patients (a closed-loop CVD control system)] and Science and Technology Planning Project of Guangdong Province (No. 2021A0505110002). Animal experiments were approved by the Animal Experimentation Ethics Committee of Sichuan University (20200714037) and were carried out following the guidelines of the Animals Ordinance, China
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 材料科学
小类 | 1 区 化学：综合 1 区 材料科学：综合 2 区 纳米科技
最新[2023]版：
大类 | 1 区 材料科学
小类 | 1 区 化学：综合 1 区 材料科学：综合 2 区 纳米科技
第一作者：
第一作者机构： [1]Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, 999077, China. [2]Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China. [3]Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Shatin, Hong Kong, 999077, China. [4]Department of Mechanical Engineering, City University of Hong Kong, Kowloon, Hong Kong, 999077, China.
共同第一作者：
通讯作者：
通讯机构： [2]Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China. [3]Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Shatin, Hong Kong, 999077, China. [4]Department of Mechanical Engineering, City University of Hong Kong, Kowloon, Hong Kong, 999077, China. [13]Centre for Nature-Inspired Engineering, City University of Hong Kong, Kowloon, Hong Kong, 999077, China. [14]School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China. [15]National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China.
推荐引用方式(GB/T 7714)：
Yang Xiao,Gao Simin,Yang Boguang,et al.Bioinspired Tumor-Targeting and Biomarker-Activatable Cell-Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization[J].Advanced science (Weinheim, Baden-Wurttemberg, Germany).2023,e2302272.doi:10.1002/advs.202302272.
APA：
Yang Xiao,Gao Simin,Yang Boguang,Yang Zhinan,Lou Feng...&Zhang Kunyu.(2023).Bioinspired Tumor-Targeting and Biomarker-Activatable Cell-Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization.Advanced science (Weinheim, Baden-Wurttemberg, Germany),,
MLA：
Yang Xiao,et al."Bioinspired Tumor-Targeting and Biomarker-Activatable Cell-Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization".Advanced science (Weinheim, Baden-Wurttemberg, Germany) .(2023):e2302272

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