机构：[1]Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.[2]Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China[3]School of Kinesiology, Shanghai University of Sport, 399 Chang Hai Road, Shanghai, 200438, China.[4]School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 611756, China.[5]Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, Shandong Province, 266000, China.
Cancer is a severe threat to human life and health and represents the main cause of death globally. Drug therapy is one of the primary means of treating cancer; however, most anticancer medications do not proceed beyond preclinical testing because the conditions of actual human tumors are not effectively mimicked by traditional tumor models. Hence, bionic in vitro tumor models must be developed to screen for anticancer drugs. Three-dimensional (3D) bioprinting technology can produce structures with built-in spatial and chemical complexity and models with accurately controlled structures, a homogeneous size and morphology, less variation across batches, and a more realistic tumor microenvironment (TME). This technology can also rapidly produce such models for high-throughput anticancer medication testing. This review describes 3D bioprinting methods, the use of bioinks in tumor models, and in vitro tumor model design strategies for building complex tumor microenvironment features using biological 3D printing technology. Moreover, the application of 3D bioprinting in vitro tumor models in drug screening is also discussed.
基金：
National
Key R&D Program of China (2018YFA0703000), the National
Natural Science Foundation of China (82072412), the
Translation Medicine National Key Science and Technology
Infrastructure (Shanghai) Open Project (TMSK-2020-118), and
the Lingang Laboratory “Seeking Outstanding Youth Program”
Open Project (LG-QS-202206-04).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|3 区材料科学：生物材料
最新[2023]版：
大类|3 区医学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.[2]Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.[2]Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
推荐引用方式(GB/T 7714)：
Mi Xuelian,Su Zhi,Yue Xiaokun,et al.3D bioprinting tumor models mimic the tumor microenvironment for drug screening[J].Biomaterials science.2023,doi:10.1039/d3bm00159h.
APA：
Mi Xuelian,Su Zhi,Yue Xiaokun,Ren Ya,Yang Xue...&Wang Jinwu.(2023).3D bioprinting tumor models mimic the tumor microenvironment for drug screening.Biomaterials science,,
MLA：
Mi Xuelian,et al."3D bioprinting tumor models mimic the tumor microenvironment for drug screening".Biomaterials science .(2023)
