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Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice

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机构： [1]Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan 610060, China [2]Department of Neurosurgery, University ofRochester, Rochester, NY 14643, USA [3]Department of Biology, Boston University, Boston, MA 02215, USA [4]Department of Medical Psychology, JiangsuUniversity Medical School, Zhenjiang 212013, China [5]Department of Neurosurgery and Neuroscience Institute, Baylor Scott & White Health, Temple,TX 76508, USA [6]George Washington University School of Medicine and Health Sciences,Washington, DC 20052, USA [7]Center for Neuroscience Research,Children’s National Research Institute, Children’s National Hospital, Washington, DC 20010, USA [8]Key Laboratory of Medical Electrophysiology, Ministry ofEducation & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou646000, China [9]Basic Medicine College, Hubei University of Chinese Medicine, Wuhan, China [10]Department of Neurosurgery, Huashan Hospital, FudanUniversity, Shanghai 200040, China [11]School of Psychology, Nanjing University of Chinese Medicine, Nanjing 210023, China [12]Brain Tumor Center, Divisionof Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA [13]Department of Pediatrics,University of Cincinnati College ofMedicine, Cincinnati,OH 45229, USA [14]Department of Neuroscience & Experimental Therapeutics, Texas A&MUniversity,Bryan, TX 77807, USA [15]Livestrong Cancer Institutes and Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712,USA [16]Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX 78712, USA [17]Department ofBiomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX 78712, USA [18]Texas A & M University Health ScienceCenter, College Station, TX 77843, USA [19]Department of Neurosurgery, Baylor College of Medicine, Temple, TX 76508, USA

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Despite extensive research on astrocytic Ca2+ in synaptic transmission, its contribution to the modulation of sensory transmission during different brain states remains largely unknown. Here, by using two-photon microscopy and whole-cell recordings, we show two distinct astrocytic Ca2+ signals in the murine barrel cortex: a small, long-lasting Ca2+ increase during sleep and a large, widespread but short-lasting Ca2+ spike when aroused. The large Ca2+ wave in aroused mice was inositol trisphosphate (IP3)-dependent, evoked by the locus coeruleus-norepinephrine system, and enhanced sensory input, contributing to reliable sensory transmission. However, the small Ca2+ transient was IP3-independent and contributed to decreased extracellular K+, hyperpolarization of the neurons, and suppression of sensory transmission. These events respond to different pharmacological inputs and contribute to distinct sleep and arousal functions by modulating the efficacy of sensory transmission. Together, our data demonstrate an important function for astrocytes in sleep and arousal states via astrocytic Ca2+ waves.© 2023. The Author(s).

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第一作者：

第一作者机构： [1]Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan 610060, China [2]Department of Neurosurgery, University ofRochester, Rochester, NY 14643, USA

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通讯作者：

通讯机构： [1]Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan 610060, China [2]Department of Neurosurgery, University ofRochester, Rochester, NY 14643, USA [5]Department of Neurosurgery and Neuroscience Institute, Baylor Scott & White Health, Temple,TX 76508, USA [15]Livestrong Cancer Institutes and Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712,USA [16]Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX 78712, USA [17]Department ofBiomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX 78712, USA [18]Texas A & M University Health ScienceCenter, College Station, TX 77843, USA [19]Department of Neurosurgery, Baylor College of Medicine, Temple, TX 76508, USA

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