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Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma

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收录情况： ◇ SCIE

作者：
Shen Yifei[1,2] ; Xu Shuaishuai[3] ; Ye Chanqi[3] ; Li Qiong[3] ; Chen Ruyin[3] ; Wu Wei[3] ; Jiang Qi[3] ; Jia Yunlu[3] ; Zhang Xiaochen[3] ; Fan Longjiang[4] ; Fu Wenguang[5] ; Jiang Ming[6] ; Chen Jinzhang[7] ; Timko Michael P[8] ; Zhao Peng[3] ; Ruan Jian[3] ;
机构： [1]Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, People’s Republic of China [2]Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou 310000, Zhejiang Province, People’s Republic of China [3]Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou 310000, Zhejiang Province, People’s Republic of China [4]Institute of Bioinformatics, Zhejiang University, Hangzhou 310000, Zhejiang Province, People’s Republic of China [5]Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, People’s Republic of China [6]The Children’s Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou 310058, Zhejiang Province, People’s Republic of China [7]Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, Guangdong Province, People’s Republic of China [8]Departments of Biology and Public Health Sciences, University of Virginia, Charlottesville, VA 22904, USA
出处：
DOI： 10.1016/j.isci.2023.106003
ISSN：

摘要：
Despite the epidemiological association between intrahepatic cholangiocarcinoma (ICC) and hepatitis B virus (HBV) infection, little is known about the relevant oncogenic effects. A cohort of 32 HBV-infected ICC and 89 non-HBV-ICC patients were characterized using whole-exome sequencing, proteomic analysis, and single-cell RNA sequencing. Proteomic analysis revealed decreased cell-cell junction levels in HBV-ICC patients. The cell-cell junction level had an inverse relationship with the epithelial-mesenchymal transition (EMT) program in ICC patients. Analysis of the immune landscape found that more CD8 T cells and Th2 cells were present in HBV-ICC patients. Single-cell analysis indicated that transforming growth factor beta signaling-related EMT program changes increased in tumor cells of HBV-ICC patients. Moreover, ICAM1+ tumor-associated macrophages are correlated with a poor prognosis and contributed to the EMT in HBV-ICC patients. Our findings provide new insights into the behavior of HBV-infected ICC driven by various pathogenic mechanisms involving decreased cell junction levels and increased progression of the EMT program.© 2023 The Author(s).

基金：
This work was supported by the National Natural Science Foundation of China (81874173, 82074208, 81472346) and Zhejiang Provincial Natural Science Foundation of China (LY20H160033, LY22H160019).
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外文
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大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2023]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
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出版当年[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES
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Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, People’s Republic of China [2]Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou 310000, Zhejiang Province, People’s Republic of China
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推荐引用方式(GB/T 7714)：
Shen Yifei,Xu Shuaishuai,Ye Chanqi,et al.Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma[J].ISCIENCE.2023,26(2):doi:10.1016/j.isci.2023.106003.
APA：
Shen Yifei,Xu Shuaishuai,Ye Chanqi,Li Qiong,Chen Ruyin...&Ruan Jian.(2023).Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma.ISCIENCE,26,(2)
MLA：
Shen Yifei,et al."Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma".ISCIENCE 26..2(2023)

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