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Effect of Arsenic Exposure and Cigarette Smoking on Total and Cause-Specific Mortality: An Occupational Cohort With 27 Follow-up Years

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机构： [1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China (Mr Jia, Ms Li) [2]Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy ofMedical Sciences and PekingUnion Medical College, Beijing, China (Mr Jia, Ms Li,Dr Zhao) [3]Tianjin Key Laboratory of Lung Cancer Metastasis and TumorMicroenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China (Dr Fan, Dr Zhou) [4]Sichuan Lung Cancer Institute, Sichuan Lung Cancer Center,West China Hospital, Chengdu, SichuanUniversity, China (Dr Zhou) [5]Center for Global Health, School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (Dr Qiao) [6]and The University of Chicago, Chicago, Illinois (Ms Lalley).

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The relationship between arsenic exposure and all-cause mortality and the joint effects of arsenic exposure and smoking have been poorly described in previous studies.After 27 years of follow-up, a total of 1738 miners were included in the analysis. Different statistical methods were used to explore the relationship between arsenic exposure and smoking and the risk of all-cause mortality and various causes of death.A total of 694 deaths occurred during the 36,199.79 person-years of follow-up. Cancer was the leading cause of death, and arsenic-exposed workers had significantly higher mortality rates for all-cause, cancer, and cerebrovascular disease. All-cause, cancer, cerebrovascular disease, and respiratory disease increased with cumulative arsenic exposure.We demonstrated the negative effects of smoking and arsenic exposure on all-cause mortality. More effective actions should be taken to reduce arsenic exposure in miners.Copyright © 2023 American College of Occupational and Environmental Medicine.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区公共卫生、环境卫生与职业卫生

最新[2023]版：

大类 | 4 区医学

小类 | 4 区公共卫生、环境卫生与职业卫生

第一作者：

第一作者机构： [1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China (Mr Jia, Ms Li) [2]Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy ofMedical Sciences and PekingUnion Medical College, Beijing, China (Mr Jia, Ms Li,Dr Zhao)

通讯作者：

通讯机构： [3]Tianjin Key Laboratory of Lung Cancer Metastasis and TumorMicroenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China (Dr Fan, Dr Zhou) [5]Center for Global Health, School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (Dr Qiao) [*1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China. [*2]Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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