机构：[1]Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing 100044, China.[2]Department of Biology, University of Richmond, Richmond, VA 23173, USA.[3]Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.[4]School of Archaeology and Museology, Sichuan University, Chengdu 610064, China.[5]Center for Archaeological Science, Sichuan University, Chengdu 610064, China.[6]School of Cultural Heritage, Northwest University, Xi'an 710069, China.[7]Key Laboratory of Western China's Environmental Systems (Ministry of Education), College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, China.[8]University of the Chinese Academy of Sciences, Beijing 100049, China.[9]School of Archaeology and Museology, Peking University, Beijing 100871, China.[10]State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.[11]Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.[12]Department of Anthropology and Heritage Studies, University of California, Merced, Merced, CA 95343, USA.[13]Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.[14]Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai 201203, China.[15]Shanghai Qi Zhi Institute, Shanghai 200232, China.
Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structure indicating high differentiation before 2500 B.P. Northeastern plateau populations rapidly showed admixture associated with millet farmers by 4700 B.P. in the Gonghe Basin. High genetic similarity on the southern and southwestern plateau showed population expansion along the Yarlung Tsangpo River since 3400 years ago. Central and southeastern plateau populations revealed extensive genetic admixture within the plateau historically, with substantial ancestry related to that found in southern and southwestern plateau populations. Over the past ~700 years, substantial gene flow from lowland East Asia further shaped the genetic landscape of present-day plateau populations. The high-altitude adaptive EPAS1 allele was found in plateau populations as early as in a 5100-year-old individual and showed a sharp increase over the past 2800 years.
基金：
This work was supported by the
National Key R&D Program of China (2021YFC1523600), Chinese Academy of Sciences (CAS)
(YSBR-019 and XDB26000000), National Natural Science Foundation of China (41925009 and
32030020), Foundation through Shanghai Qi Zhi Institute, Tencent Foundation through the
XPLORER PRIZE, and the Howard Hughes Medical Institute (grant no. 55008731). X.W. was
supported by Key National Social Science Foundation of China (no. 16ZDA144). S.X. was
supported by the Basic Science Center Program (32288101) and the Shanghai Municipal
Science and Technology Major Project (2017SHZDZX01).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|1 区综合性期刊
小类|1 区综合性期刊
最新[2023]版：
大类|1 区综合性期刊
小类|1 区综合性期刊
第一作者：
第一作者机构：[1]Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing 100044, China.
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing 100044, China.[8]University of the Chinese Academy of Sciences, Beijing 100049, China.[15]Shanghai Qi Zhi Institute, Shanghai 200232, China.
推荐引用方式(GB/T 7714)：
Wang Hongru,Yang Melinda A,Wangdue Shargan,et al.Human genetic history on the Tibetan Plateau in the past 5100 years[J].Science advances.2023,9(11):eadd5582.doi:10.1126/sciadv.add5582.
APA：
Wang Hongru,Yang Melinda A,Wangdue Shargan,Lu Hongliang,Chen Honghai...&Fu Qiaomei.(2023).Human genetic history on the Tibetan Plateau in the past 5100 years.Science advances,9,(11)
MLA：
Wang Hongru,et al."Human genetic history on the Tibetan Plateau in the past 5100 years".Science advances 9..11(2023):eadd5582
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