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High PD-L1 expression associates with low T-cadherin expression and poor prognosis in human papillomavirus-negative head and neck squamous cell carcinoma

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收录情况： ◇ SCIE

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机构： [1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China [2]The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

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This study aimed at exploring the correlation between T-cadherin and programmed death-ligand 1 (PD-L1), as well as their prognostic value in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC).Immunohistochemical staining was used to identify the protein expression of T-cadherin and PD-L1. Spearman linear correlation analysis was used to determine their association. Kaplan-Meier analysis was utilized to plot overall survival (OS) and disease-free survival (DFS) curves. Cox proportional hazards regression was used to conduct univariate and multivariate analysis.The results showed a negative association between protein expression of T-cadherin and PD-L1 (r = -0.760, p < 0.001), positive expression of T-cadherin was associated with a better OS (p < 0.001) and DFS (p < 0.001), while positive PD-L1 expression was associated with a worse OS (p = 0.002) and DFS (p < 0.001). The expression of T-cadherin and PD-L1 were independent prognostic predictors for OS and DFS.In conclusion, expression of T-cadherin and PD-L1 were largely inversely correlated and independent prognostic factors for patients with HPV-negative HNSCC.© 2023 Wiley Periodicals LLC.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区耳鼻喉科学 3 区外科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区耳鼻喉科学 3 区外科

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出版当年[2023]版：

Q1 OTORHINOLARYNGOLOGY Q2 SURGERY

最新[2023]版：

Q1 OTORHINOLARYNGOLOGY Q2 SURGERY

影响因子： 2.3 最新[2023版] 2.8 最新五年平均 2.3 出版当年[2023版] 2.8 出版当年五年平均 2.9 出版前一年[2022版]

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第一作者机构： [1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

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通讯机构： [1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China [*1]Sichuan Cancer Hospital & Institute, No. 55 South Renmin Road, Wuhou District, Chengdu, China

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