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Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma and chronic liver disease mortality

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机构: [1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. [2]Department of Epidemiology and Biostatistics, West China, School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, P.R. China. [3]Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. [4]Department of Epidemiology, School of Public Health, Fudan University, Shanghai, P.R. China. [5]Slone Epidemiology Center, Boston University, Boston, MA, USA. [6]Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA. [7]Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. [8]Department of Gastroenterology, Kaiser Permanente Northern California, San Francisco, California, USA. [9]Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. [10]Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. [11]Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, P.R. China. [12]Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, MD, USA. [13]Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. [14]The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH, USA.
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Diet modulates inflammation and insulin response and may be an important modifiable factor in the primary prevention of hepatocellular carcinoma (HCC) and chronic liver disease (CLD). We developed the empirical dietary inflammatory pattern (EDIP) and empirical dietary index for hyperinsulinemia (EDIH) scores to assess the inflammatory and insulinemic potentials of diet.We prospectively examined the associations of EDIP and EDIH at baseline with the following HCC risk and CLD mortality.We followed 485,931 individuals in the NIH-AARP Diet and Health Study since 1995. Cox proportional hazards regression was used to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95%CIs).We confirmed 635 incident HCC cases and 993 CLD deaths. Participants in the highest compared to those in the lowest EDIP quartile had 1.35 times higher risk of developing HCC (95% CI: 1.08-1.70, Ptrend =0.0005), and had 1.70 times higher CLD mortality (95% CI: 1.41-2.04, Ptrend <0.0001). For the same comparison, participants with highest EDIH were at increased risk of HCC (HR = 1.53, 95% CI: 1.20-1.95, Ptrend =0.0004), and CLD mortality (HR = 1.72, 95% CI: 1.42-2.01, Ptrend <0.0001). Similar positive associations of scores with HCC risk and CLD mortality were observed for both women and men. Moreover, individuals in both highest EDIP and EDIH tertiles had 92% increased HCC risk (95% CI: 1.43-2.58) and had 98% increased CLD mortality (95% CI: 1.27-3.08), compared with those in both lowest tertiles.Our findings suggest that inflammation and hyperinsulinemia are potential mechanisms linking diet to HCC development and CLD mortality.© The Author(s) 2023. Published by Oxford University Press.

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第一作者机构: [1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. [2]Department of Epidemiology and Biostatistics, West China, School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, P.R. China.
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通讯机构: [1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. [3]Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. [*1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Room 453, Boston, MA 02115, USA
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