机构：[1]Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, P. R. China. dengdawei@cpu.edu.cn.[2]Department of Ultrasound, West China Hospital, College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610041, P. R. China. matian1991@scu.edu.cn.四川大学华西医院[3]Institute of Orthopedics, The First Medical Center, Beijing Key Lab of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing, 100853, P. R. China.[4]Med-X Center for Materials, Sichuan University, Chengdu, 610065, P. R. China.
Engineering chem-/sono-/photo-multimodal antitumor therapies has become an efficient strategy to combat malignant tumors. However, the existence of hypoxia in the tumor microenvironment (TME) leads to limited sonodynamic or photodynamic efficiency because O2 is the key reactant during the process of generation of reactive oxygen species (ROS). Here, to design a desirable platform that can simultaneously convert H2O2 in the TME into ROS and O2 for efficient chem-/sono-/photo-multimodal tumor therapies, we have created ultrasmall Cu2O-coordinated carbon nitride on a biocompatible ceria substrate (denoted as Cu2O-CNx@CeO2) via a self-assisted catalytic growth strategy. The chemical and morphological structures, ROS and O2 generation activities, and chemo-/photo-/sono-dynamic specificities of Cu2O-CNx@CeO2 when serving as multifunctional biocatalytic agents were systematically disclosed. The experimental studies validated that Cu2O-CNx@CeO2 presents state-of-the-art peroxidase-like and catalase-like activities. Moreover, the light excitation and ultrasound irradiation were also demonstrated to boost ROS production. The in vitro and in vivo experiments suggest that Cu2O-CNx@CeO2 can efficiently inhibit the growth of malignant melanoma via chem-/sono-/photo-multimodal antitumor ability. We believe that applying these new biocatalysts with dual catalytic activities of producing ROS and O2 will offer a new path for engineering multimodal nanoagents to combat malignant tumors.
基金：
This work
was financially supported by the National Key R&D Program ofChina (No. 2021YFE0205000), the National Natural Science
Foundation of China (No. 82172085, 52173133, and 82102065),
the Science and Technology Project of Sichuan Province
(No. 2021YFH0135, 2022YFH0111, and 2022YFH0042), the Key
Laboratory of Emergency and Trauma, Ministry of Education (No.
KLET-201907), the 135 Project for Disciplines of Excellence, West
China Hospital, Sichuan University (No. ZYJC21047), the innovation
project of Med-X Center for Materials, Sichuan University
(No. MCM202102), the Chinese Postdoctoral Science Foundation
(No. 2021M692303), the full-time Postdoctoral Foundation of
Sichuan University (No. 2021SCU12013 and 2022SCU12051), and
the Post-Doctor Research Project, West China Hospital, Sichuan
University (No. 2021HXBH058). Prof. Cheng acknowledges the
financial support of the State Key Laboratory of Polymer Materials
Engineering (Grant No. sklpme2021-4-02).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区材料科学
小类|2 区化学：综合2 区材料科学：综合
最新[2023]版：
大类|2 区材料科学
小类|2 区化学：综合2 区材料科学：综合
第一作者：
第一作者机构：[1]Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, P. R. China. dengdawei@cpu.edu.cn.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Ultrasound, West China Hospital, College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610041, P. R. China. matian1991@scu.edu.cn.[4]Med-X Center for Materials, Sichuan University, Chengdu, 610065, P. R. China.
推荐引用方式(GB/T 7714)：
Cao Lijian,Feng Ziyan,Guo Ruiqian,et al.The direct catalytic synthesis of ultrasmall Cu2O-coordinated carbon nitrides on ceria for multimodal antitumor therapy[J].Materials horizons.2023,doi:10.1039/d2mh01540d.
APA：
Cao Lijian,Feng Ziyan,Guo Ruiqian,Tian Qinyu,Wang Weiwen...&Deng Dawei.(2023).The direct catalytic synthesis of ultrasmall Cu2O-coordinated carbon nitrides on ceria for multimodal antitumor therapy.Materials horizons,,
MLA：
Cao Lijian,et al."The direct catalytic synthesis of ultrasmall Cu2O-coordinated carbon nitrides on ceria for multimodal antitumor therapy".Materials horizons .(2023)
