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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

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收录情况: ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越:领军期刊

机构: [1]Center of Interventional Radiology & Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. [2]Department of Minimally invasive Intervention, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China. [3]Department of Interventional Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China. [4]Department of Interventional Radiology, Union Hospital of Fujian Medical University, Fuzhou 350001, China. [5]Department of Interventional Radiology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China. [6]Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China. [7]Hepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. [8]Department of Interventional Radiology, Eastern Hospital of Hepatobiliary Surgery, Navy Medical University (Second Military Medical University), Shanghai 200438, China. [9]Department of Interventional Radiology, Nantong First People’s Hospital, Nantong 226001, China. [10]Department of Interventional Radiology, Yancheng Third People’s Hospital, Yancheng 224008, China. [11]Department of Minimally Invasive Interventional Therapy, Sun Yat- Sen University Cancer Center, Guangzhou 510060, China. [12]Department of Vascular Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China. [13]Department of Interventional Radiology, Hunan Cancer Hospital, Changsha 410031, China. [14]Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. [15]Department of Interventional Radiology, The Hospital of Nantong University, Nantong 226001, China. [16]Department of Interventional Therapy, Shanxi Tumor Hospital, Taiyuan 030001, China. [17]Department of Interventional Radiology, Tibet Autonomous Region People’s Hospital, Lhasa 850000, China. [18]Department of Interventional Radiology, Ganzhou People’s Hospital, Ganzhou 341000, China. [19]Center of Interventional Oncology and Liver Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. [20]Department of Interventional Radiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, China. [21]Department of Minimally Invasive Interventional Therapy, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China. [22]Department of Radiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China. [23]Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. [24]Department of Interventional Radiology, Affiliated Hospital of Qingdao University, Qingdao 266000, China. [25]Department of Interventional Therapy, Peking University Cancer Hospital and Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China. [26]Department of Interventional Radiology, Affiliated Cancer Hospital of Shandong First Medical University, Jinan 250117, China. [27]Interventional Therapy Center, The first Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China. [28]Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 830011, China. [29]Department of Interventional Oncology, Tianjin Medical University Cancer Hospital, Tianjin 300060, China. [30]Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China. [31]Department of Tumor Interventional Therapy, Fujian Cancer Hospital, Fuzhou 350014, China. [32]Department of Radiology, The Second Xiangya Hospital, Changsha 410011, China. [33]Department of Interventional Radiology, Sichuan Cancer Hospital and Institute, Chengdu 610041, China. [34]Department of Interventional Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. [35]Department of Hepatobiliary Oncology Surgery, Department of Interventional Oncology, Jiangxi Cancer Hospital of Nanchang University, Nanchang 330029, China. [36]Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang 110001, China. [37]Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 110001, China. [38]Department of Interventional Radiology, General hospital of Ningxia Medical University, Yinchuan 110001, China. [39]Department of Interventional Radiology, Guizhou Cancer Hospital, Guiyang 550000, China. [40]Department of Interventional Radiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, China. [41]Department of Interventional Radiology, Third Affiliated Hospital of Soochow University, Changzhou First Hospital, Changzhou 213004, China. [42]Department of Interventional and Vascular Surgery, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou 213003, China. [43]Department of Interventional Therapy, Nantong Tumor Hospital, Nantong 226006, China. [44]Department of Interventional Therapy, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China. [45]Department of Interventional Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214122, China. [46]Department of Interventional Radiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China. [47]Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China. [48]Department of Interventional Radiology, The Second Hospital of Nanjing, Nanjing 210000, China. [49]Department ofOncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan 030001, China. [50]Vascular and Interventional Department, Chongqing University Cancer Hospital, Chongqing 400000, China. [51]Department of Interventional Radiology, The Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China. [52]Department of Interventional Therapy, The First Hospital of Jilin University, Changchun 130000, China. [53]Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. [54]Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. [55]Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, School of Medicine, Lishui Hospital of Zhejiang University, Lishui 323000, China. [56]Department of Interventional Radiology, Shanxi Provincial People’s Hospital, Taiyuan 030012, China. [57]Department of Interventional Medicine, The Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China. [58]Department of Interventional & Vascular Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, China. [59]Department of Biostatistics, Nanjing Medical University, Nanjing 211166, China. [60]Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Jinan University, Zhuhai 519000, China.
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There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC). It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations. In this nationwide, retrospective, cohort study, 826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT (combination group, n = 376) or TACE monotherapy (monotherapy group, n = 450) were included from January 2018 to May 2021. The primary endpoint was progression-free survival (PFS) according to modified RECIST. The secondary outcomes included overall survival (OS), objective response rate (ORR), and safety. We performed propensity score matching approaches to reduce bias between two groups. After matching, 228 pairs were included with a predominantly advanced disease population. Median PFS in combination group was 9.5 months (95% confidence interval [CI], 8.4-11.0) versus 8.0 months (95% CI, 6.6-9.5) (adjusted hazard ratio [HR], 0.70, P = 0.002). OS and ORR were also significantly higher in combination group (median OS, 19.2 [16.1-27.3] vs. 15.7 months [13.0-20.2]; adjusted HR, 0.63, P = 0.001; ORR, 60.1% vs. 32.0%; P < 0.001). Grade 3/4 adverse events were observed at a rate of 15.8% and 7.5% in combination and monotherapy groups, respectively. Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS, OS, and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice, with an acceptable safety profile.© 2022. The Author(s).

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出版当年[2023]版:
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
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出版当年[2023]版:
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY
最新[2023]版:
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

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第一作者机构: [1]Center of Interventional Radiology & Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
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