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Virtual elastography ultrasound via generative adversarial network for breast cancer diagnosis

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机构: [1]School of Information Science and Technology, Fudan University, Shanghai,China. [2]Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. [3]Department of Medical Ultrasound, Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China. [4]Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China. [5]Department of Ultrasound, Minhang Hospital, Fudan University, Shanghai 201199, China. [6]Department of Ultrasonography, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China. [7]Department of Ultrasound, Shenzhen People’sHospital, Guangzhou, Guangdong, China. [8]Department of Ultrasound Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China. [9]Department of Ultrasound, People’s Hospital of Henan Province, Zhengzhou 450000, China. [10]Department of Ultrasound Diseases, Tangdu Hospital, Four Military Medical University, Xi’an 710038, China. [11]Department of Ultrasound, Sichuan Provincial People’s Hospital,University of ElectronicScience and Technology ofChina,Chengdu 610072,China. [12]Department of Ultrasound, Sun Yat-senMemorialHospital, Sun Yat-sen University, Guangzhou 510120, China. [13]Department of Ultrasound, General Hospital of Northern Theater Command, 110000 Shenyang, China. [14]Department of Ultrasound, Affiliated Hangzhou First people’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. [15]Department of Ultrasound, The Third Xiangya Hospital of Central South University, Changsha 410013, China. [16]Department of Ultrasound, Peking University Third Hospital, Beijing 100191,China. [17]Department of Ultrasound, Beijing Friendship Hospital,Capital MedicalUniversity, Beijing 100050, China. [18]Department ofUltrasound, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China. [19]Department of Ultrasound, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China.
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Elastography ultrasound (EUS) imaging is a vital ultrasound imaging modality. The current use of EUS faces many challenges, such as vulnerability to subjective manipulation, echo signal attenuation, and unknown risks of elastic pressure in certain delicate tissues. The hardware requirement of EUS also hinders the trend of miniaturization of ultrasound equipment. Here we show a cost-efficient solution by designing a deep neural network to synthesize virtual EUS (V-EUS) from conventional B-mode images. A total of 4580 breast tumor cases were collected from 15 medical centers, including a main cohort with 2501 cases for model establishment, an external dataset with 1730 cases and a portable dataset with 349 cases for testing. In the task of differentiating benign and malignant breast tumors, there is no significant difference between V-EUS and real EUS on high-end ultrasound, while the diagnostic performance of pocket-sized ultrasound can be improved by about 5% after V-EUS is equipped.© 2023. The Author(s).

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大类 | 1 区 综合性期刊
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Q1 MULTIDISCIPLINARY SCIENCES
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Q1 MULTIDISCIPLINARY SCIENCES

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第一作者机构: [1]School of Information Science and Technology, Fudan University, Shanghai,China.
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