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Aggregation-induced bioprobe for plasma membrane-specific imaging and photodynamic cancer cell ablation

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机构： [1]Core Facility of West China Hospital, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [2]Laboratory of Heart Valve Disease, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [3]Huaxi MR Research Center (HMRRC), Department of Radiology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [4]Institute of Materials, Chinese Academy of Engineering Physics, Jiangyou 621908, PR China [5]Laboratory of Liver Transplantation, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [6]Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China

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Selective labelling of the plasma membrane (PM) by fluorescence imaging techniques enables an intuitive analysis of cell status together with dynamic changes, and therefore is of great value. We herein disclose a novel carbazole-based probe, CPPPy, that shows aggregation-induced emission (AIE) property and is observed to selectively accumulate at the PM of living cells. Benefiting from its good biocompatibility and PM-targeted specificity, CPPPy can light up the PM of cells by high-resolution imaging even at a low concentration of 200 nM. Simultaneously, CPPPy is capable of generating both singlet oxygen and free radical-dominated species upon visible light irradiation, which further induces irreversible growth inhibition and necrocytosis of tumor cells. This study thus provides new insight into the construction of multifunctional fluorescence probes with PM-specific bioimaging and photodynamic therapy.Copyright © 2023 Elsevier B.V. All rights reserved.

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出版当年[2023]版：

大类 | 2 区化学

小类 | 2 区光谱学

最新[2023]版：

大类 | 2 区化学

小类 | 2 区光谱学

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第一作者机构： [1]Core Facility of West China Hospital, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China

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通讯机构： [2]Laboratory of Heart Valve Disease, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [3]Huaxi MR Research Center (HMRRC), Department of Radiology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [5]Laboratory of Liver Transplantation, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [6]Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China [*1]Laboratory of Heart Valve Disease, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, PR China (M. Chen).

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