详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma

文献详情

资源类型：

Pubmed体系：

收录情况： ◇ 自然指数

作者：

机构： [1]Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, China. [2]Institute of Clinical Pathology, West China Hospital, Sichuan University, Chengdu, China. [3]Research Core Facility of West China Hospital, Sichuan University, Chengdu, China. [4]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China. [5]Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada. [6]Department of Biotherapy and National Clinical Research Center for Geriatrics, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. [7]MinSheng Ear-Nose-Throat Hospital, Chengdu, China. [8]Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China. [9]Department of Biostatistics, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, Toronto, Canada. [10]Department of Medicine, Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Canada.

出处：

DOI：

摘要：

The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8+ T cells (Tex) in HNSCC. We performed cell-level multi-omics sequencing on human HNSCC samples to decipher the multi-dimensional characteristics of Tex cells. A proliferative exhausted CD8+ T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects.© 2023, Cheng, Qiu, Rao et al.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 1 区

生物学

小类 | 1 区生物学

最新[2025]版：

大类 | 1 区

生物学

小类 | 1 区生物学

第一作者：

第一作者机构： [1]Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, China. [4]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

日	一	二	三	四	五	六

今天

清空