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Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population

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资源类型：
Pubmed体系：
作者：
Zhang Shaoyuan[1,2] * ; Fang Yong[1,2] ; Su Feng[1,2] ; Jiang Tian[1,2] ; Yu Jinjie[1,2] ; Lin Siyun[1,2] ; Lv Lu[3] ; Long Tao[3] ; Pan Huiwen[3] ; Qi Junqing[3] ; Zhou Qiang[4] ; Tang Weifeng[5] ; Ding Guowen[3] ; Wang Liming[6] ; Tan Lijie[1,2] ; Yin Jun[1,2] ;
机构： [1]Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [2]Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [3]Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Jiangsu 212002, China. [4]Department of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Sichuan 610042, China. [5]Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Jiangsu 210008, China. [6]Department of Respiratory, Shanghai Xuhui Central Hospital, Shanghai 200031, China.
出处：
DOI： 10.1155/2023/6922909
ISSN：

摘要：
LAMA1, also known as laminin subunit α1, is a member of the laminin family, which is widely reported to be a key basement membrane molecule that affects various biological activities and is associated with many kinds of diseases. We aimed to investigate the association between LAMA1single-nucleotide polymorphisms and the occurrence and progression of esophageal squamous cell carcinoma in the Chinese population.2,186 participants were collected retrospectively between October 2008 and January 2017, including 1,043 ESCC patients and 1,143 noncancer patients. A 2 mL blood sample was obtained intravenously for the LDR for SNP analysis. The 6 SNP loci of LAMA1 were selected and examined. We analyzed the association of several genetic models of 6 LAMA1 SNP loci, sex, age, smoking and drinking status, and the occurrence of esophageal squamous cell carcinoma.In the rs62081531 G > A locus, genotype GA was a protective factor for ESCC compared with GG (OR: 0.830, P=0.046), especially among the younger and nondrinkers. At rs607230 T > C, genotype TC was linked with a lower risk of ESCC compared with TT. (OR: 0.613, P=0.034). Haplotype Frequencies revealed that Ars62081531Grs621993Ars539713Trs566655Ars73938538Crs607230 (OR: 0.803, P=0.028) and Grs62081531Grs621993Ars539713Trs566655Crs73938538Crs607230 (OR: 0.679, P=0.010) were strongly associated with lower susceptibility of ESCC.The LAMA1 rs62081531, rs539713, rs566655, and rs607230 polymorphisms were demonstrated to be related to susceptibility to ESCC in the Chinese population. LAMA1 SNPs may have a significant impact on the occurrence of esophageal cancer and may serve as potential diagnostic biomarkers.Copyright © 2023 Shaoyuan Zhang et al.

基金：
,is study was supported by the National Natural Science Foundation of China (81370001, 81300037, 81000028, 81570031, 81101889, 81472332, and 81341006); the Key Research and Development Program of Jiangsu Province (BE2016714); the Natural Science Foundation of Jiangsu Province (BK2010333 and BK2011481); the “333” Elitist Training Program, Jiangsu, China (BRA2013135 and BRA2017129); the “Six Talent Peaks” Training Program, Jiangsu, China (2015-WSN-117 and 2014-WSN-078); the “Distinguished Medical Specialist” Program, Jiangsu, China; the “Innovative and Entrepreneurial Elite Team” Program (2016), Jiangsu, China; the research funding of the Shanghai Hospital Development Center (SHDC12018X12 and SHDC2020CR4039); the Natural Science Foundation of Shanghai (19ZR1449900 and 20ZR1411600); 2021 Clinical Research Navigation Program of the Shanghai Medical College of Fudan University (grant number: DGF501035/ 002); and the Shanghai Xuhui District Medical Research Project (SHXH201805).
语种：
外文
PubmedID：
第一作者：
第一作者机构： [1]Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [2]Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
通讯作者：
通讯机构： [1]Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [2]Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
推荐引用方式(GB/T 7714)：
Zhang Shaoyuan,Fang Yong,Su Feng,et al.Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population[J].Journal of oncology.2023,2023:6922909.doi:10.1155/2023/6922909.
APA：
Zhang Shaoyuan,Fang Yong,Su Feng,Jiang Tian,Yu Jinjie...&Yin Jun.(2023).Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population.Journal of oncology,2023,
MLA：
Zhang Shaoyuan,et al."Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population".Journal of oncology 2023.(2023):6922909

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