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Longitudinal patient-reported outcomes 1 year after thoracoscopic segmentectomy versus lobectomy for early-stage lung cancer: a multicentre, prospective cohort study protocol

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收录情况： ◇ SCIE

作者：
Gao Xin[1] * ; Dai Wei[1] * ; Zhang Qi[1,2] * ; Liu Wenwu[1] ; Liu Yangjun[3] ; Yang Lingjia[4] ; Wei Xing[1] ; Shi Qiuling[5,6] ; Pompili Cecilia[7,8] ; Pu Yang[6] ; Xie Shaohua[1] ; Xiang Run[1] ; Tian Bo[1] ; Hu Bin[1] ; Yang Xiaozun[1] ; Wang Xiang[1] ; Yang Xiaojun[1] ; Xie Tianpeng[1] ; Tang Yong[9] ; Qiao Guibin[9] ; Sun Nan[10] ; Gao Shan[11] ; Zhang Guangjian[11] ; Chen Dan[12] ; Cui Yue[13] ; Chen Xiaobo[13] ; He Yu[14] ; Zhang Rong[14] ; Li Qiang[1] ; Zhuang Xiang[1] ;
机构： [1]Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, SichuanCancer Center, University of Electronic Science and Technology of China, Chengdu,Sichuan, China [2]Graduate School, Chengdu Medical College, Chengdu, Sichuan, China [3]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet,Stockholm, Sweden [4]College of Medical and Dental Science, University of Birmingham, Birmingham, UK [5]Center for Cancer Prevention Research, Sichuan Cancer Hospital & Institute,Sichuan Cancer Center, University of Electronic Science and Technology of China,Chengdu, Sichuan, China [6]School of Public Health, Chongqing Medical University, Chongqing, China [7]Thoracic Surgery Unit, University and Hospital Trust - Ospedale Borgo Trento,Verona, Italy [8]Section of Patient Centered Outcomes Research, Leeds Institute of MedicalResearch at St James's, University of Leeds, Leeds, UK [9]Department of Thoracic Surgery, Guangdong Provincial People's Hospital,Guangzhou, Guangdong, China [10]Department of Thoracic Surgery, Liaoning Cancer Hospital & Institute, Shenyang,Liaoning, China [11]Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an JiaotongUniversity, Xi'an, Shaanxi, China [12]Department of Thoracic Surgery, The First Affiliated Hospital of Chongqing MedicalUniversity, Chongqing, Chongqing, China [13]Department of Thoracic Surgery, First Affiliated Hospital of Kunming MedicalUniversity, Kunming, Yunnan, China [14]Department of Thoracic Surgery, Ya'an People's Hospital, Ya'an, Sichuan, China
出处：
DOI： 10.1136/bmjopen-2022-067841
ISSN：

摘要：
Segmentectomy and lobectomy are the main surgical procedures for early-stage lung cancer. However, few studies have analysed patient-reported outcomes after segmentectomy versus lobectomy. This study aims to compare patient-reported outcomes-such as symptoms, daily functioning and quality of life-between thoracoscopic segmentectomy and lobectomy for early-stage lung cancer during the 1 year after surgery.Overall, 788 newly diagnosed patients with early-stage lung cancer (tumour size ≤2 cm), who are scheduled to undergo thoracoscopic segmentectomy or lobectomy, will be recruited in this multicentre, prospective cohort study. The patients will receive standardised care after surgery. The Perioperative Symptom Assessment for Lung Surgery-a validated lung cancer surgery-specific scale-will be used to assess the symptoms and functions at baseline, at discharge and monthly after discharge for 1 year. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and Lung Cancer module 29 will be used to assess the patients' quality of life at the same time points. The primary outcome will be the shortness of breath scores during the first year after thoracoscopic segmentectomy and lobectomy and will be compared using mixed-effects models. The secondary outcomes will include other symptoms, indicators of daily functioning, quality of life scores and traditional clinical outcomes. These will be compared using mixed-effects models and the Student's t-test, non-parametric test or Χ2 test. Propensity score matching will be used to ensure an even distribution of known confounders between the groups.The Ethics Committee for Medical Research and New Medical Technology of Sichuan Cancer Hospital approved this study (approval number: SCCHEC-02-2022-002). All participants will be instructed to provide informed consent. The manuscript is based on protocol version 3.0. The study results will be presented at medical conferences and published in peer-reviewed journals.ChiCTR2200060753.© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

基金：
Bethune Charitable Foundation (grant number CESS2021TC01), Sichuan Science and Technology Program (grant number 2019YFG0517) and Clinical Key Specialty Construction Project Funding of Sichuan Province.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学：内科
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学：内科
JCR分区：
出版当年[2023]版：
Q1 MEDICINE, GENERAL & INTERNAL
最新[2023]版：
Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, SichuanCancer Center, University of Electronic Science and Technology of China, Chengdu,Sichuan, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Gao Xin,Dai Wei,Zhang Qi,et al.Longitudinal patient-reported outcomes 1 year after thoracoscopic segmentectomy versus lobectomy for early-stage lung cancer: a multicentre, prospective cohort study protocol[J].BMJ OPEN.2023,13(1):doi:10.1136/bmjopen-2022-067841.
APA：
Gao Xin,Dai Wei,Zhang Qi,Liu Wenwu,Liu Yangjun...&Zhuang Xiang.(2023).Longitudinal patient-reported outcomes 1 year after thoracoscopic segmentectomy versus lobectomy for early-stage lung cancer: a multicentre, prospective cohort study protocol.BMJ OPEN,13,(1)
MLA：
Gao Xin,et al."Longitudinal patient-reported outcomes 1 year after thoracoscopic segmentectomy versus lobectomy for early-stage lung cancer: a multicentre, prospective cohort study protocol".BMJ OPEN 13..1(2023)

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