机构：[1]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.[2]Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, 110 Xiangya Road, Changsha 410078, China.[3]Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, China.[4]National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, China.[5]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[6]Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[7]Department of Pathology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.
Early intervention in rheumatoid arthritis (RA) is critical for optimal treatment, but initiation of pharmacotherapy to prevent damage remains unsatisfactory currently. Manipulation of the gut microbiome and microbial metabolites can be effective in protecting against RA. Thus, probiotics can be utilized to explore new strategies for preventing joint damage. The aim of this study was to explore the metabolites and mechanisms by which Bifidobacterium pseudocatenulatum affects RA. Based on 16S rRNA sequencing and UPLC-MS/MS assays, we focused on bile acid (BA) metabolism. In a collagen-induced arthritis (CIA) mouse model, B. pseudocatenulatum prevented joint damage by protecting the intestinal barrier and reshaped gut microbial composition, thereby elevating bile salt hydrolase (BSH) enzyme activity and increasing the levels of unconjugated secondary BAs to suppress aberrant T-helper 1/17-type immune responses; however, these benefits were eliminated by the Takeda G protein-coupled receptor 5 (TGR5) antagonist SBI-115. The results suggested that a single bacterium, B. pseudocatenulatum, can prevent RA, indicating that prophylactic administration of probiotics may be an effective therapy.
基金：
National Key Research and Development Program
(No. 2021YFA1301200), the National Scientific Foundation of China (No. 82073945, 81874329, and
81974513), the Project Program of National Clinical Research Center for Geriatric Disorders (Xiangya
Hospital, Grant No. 2020LNJJ06), and the Fundamental Research Funds of Central South
University (2020zzts276).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|2 区营养学
最新[2023]版：
大类|2 区医学
小类|2 区营养学
第一作者：
第一作者机构：[1]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.[2]Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, 110 Xiangya Road, Changsha 410078, China.[3]Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, China.[4]National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, China.
通讯作者：
通讯机构：[1]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.[2]Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, 110 Xiangya Road, Changsha 410078, China.[3]Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, China.[4]National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, China.
推荐引用方式(GB/T 7714)：
Zhao Qing,Ren Huan,Yang Nian,et al.Bifidobacterium pseudocatenulatum-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut-Joint Axis[J].Nutrients.2023,15(2):doi:10.3390/nu15020255.
APA：
Zhao Qing,Ren Huan,Yang Nian,Xia Xuyang,Chen Qifeng...&Zhang Wei.(2023).Bifidobacterium pseudocatenulatum-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut-Joint Axis.Nutrients,15,(2)
MLA：
Zhao Qing,et al."Bifidobacterium pseudocatenulatum-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut-Joint Axis".Nutrients 15..2(2023)
