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b-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility

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收录情况： ◇ SCIE

作者：
Xiaofeng Li[1,2] * ; Chun Yuan[3] * ; Jianwu Shi[4] * ; Hang Kang[4] ; Yufei Chen[4] ; Yonggang Duan[5] ; Jing Jin[2] ; Lai Ping Cheung[6] ; Tin Chiu Li[6] ; Ying Liu[3] ; Yugui Cui[3] ; Ye Chun Ruan[2,10] ; Xiaohua Jiang[2,7] ; Zhiming Cai[8] ; Hsiao Chang Chan[2,7,9] ; Ling Ji[1] ; Xuhui Zeng[4] ; Jiaying Liu[3] ; Hao Chen[4] ; Kin Lam Fok[2,7,9] ;
机构： [1]Department of Laboratory Medicine, Peking University Shenzhen Hospital, Lianhua Road No. 1120, Futian District, Shenzhen, PR China [2]Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, HongKong SAR, PR China [3]State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing MedicalUniversity, Nanjing, PR China [4]Institute of Reproductive Medicine, Medical School of Nantong University, Nantong, PR China [5]The University of Hong Kong-Shenzhen Hospital, Shenzhen, PR China [6]Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China [7]School of Biomedical Sciences Core Laboratory, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China [8]Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University,Shenzhen, PR China [9]Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second UniversityHospital, Chengdu, PR China [10]Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, PR China
出处：
DOI： 10.1016/j.xcrm.2022.100825
ISSN：

摘要：
Sperm chemotaxis is required for guiding sperm toward the egg. However, the molecular identity of physiological chemoattractant and its involvement in infertility remain elusive. Here, we identify DEFB19/119 (mouse/human orthologs) as a physiological sperm chemoattractant. The epithelia of the female reproductive tract and the cumulus-oocyte complex secrete DEFB19/119 that elicits calcium mobilization via the CatSper channel and induces sperm chemotaxis in capacitated sperm. Manipulating the level of DEFB19 in mice determines the number of sperm arriving at the fertilization site. Importantly, we identify exon mutations in the DEFB119 gene in idiopathic infertile women with low level of DEFB119 in the follicular fluid. The level of DEFB119 correlates with the chemotactic potency of follicular fluid and predicts the infertile outcome with positive correlation. This study reveals the pivotal role of DEFB19/119 in sperm chemotaxis and demonstrates its potential application in the diagnosis of idiopathic infertility.Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
National Key R&D Program of China (2022YFC2703202 and 2018YFC1003602 to H.C.), National Natural Science Foundation of China (81801517 to L.X.F., 81771639 to K.L.F, 81671432, 81871202 to H.C., 81871201 to X.H.Z., 81901449 to C.Y., 82104216), National 973 project (2013CB967401 and 2013CB967404 to H.C.C.), General Research Fund of Research Grant Council of Hong Kong (CUHK 14101114 to H.C.C., 14120015 to H.C.C., 14129316 to K.L.F. and H.C.C., 14127316 to K.L.F.), Food and Health Bureau of Hong Kong (06170476 to K.L.F.), Lo Kwee Seong Start-up fund to K.L.F., Shenzhen Project of Science and Technology (grant no. JCYJ20190809094407602) to L.X.F, Jiangsu Innovation and Entrepreneurship Talent Plan ( to H.C., No. JSSCRC20211543 to X.H.Z.), the Scientific Research Foundation of Peking University Shenzhen Hospital (KYQD2021104) to L.X.F., Natural Science Foundation of Jiangsu Province (BK20191076) to C.Y., Guangdong Basic and Applied Basic Research Foundation to L.X.F., and the fund of Sanming Project of Medicine in Shenzhen (No. SZSM201812088).
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验 2 区 细胞生物学
JCR分区：
出版当年[2022]版：
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Laboratory Medicine, Peking University Shenzhen Hospital, Lianhua Road No. 1120, Futian District, Shenzhen, PR China [2]Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, HongKong SAR, PR China
共同第一作者：
通讯作者：
通讯机构： [2]Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, HongKong SAR, PR China [7]School of Biomedical Sciences Core Laboratory, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China [9]Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second UniversityHospital, Chengdu, PR China
推荐引用方式(GB/T 7714)：
Xiaofeng Li,Chun Yuan,Jianwu Shi,et al.b-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility[J].CELL REPORTS MEDICINE.2022,3(12):doi:10.1016/j.xcrm.2022.100825.
APA：
Xiaofeng Li,Chun Yuan,Jianwu Shi,Hang Kang,Yufei Chen...&Kin Lam Fok.(2022).b-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.CELL REPORTS MEDICINE,3,(12)
MLA：
Xiaofeng Li,et al."b-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility".CELL REPORTS MEDICINE 3..12(2022)

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