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Single-cell technologies: From research to application

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机构： [1]Biomedical Pioneering Innovation Centre (BIOPIC), Peking University, Beijing 100871, China. [2]Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China. [3]School of Chemical Engineering and Technology, Sun Yat-Sen University, Zhuhai 519082, China. [4]Mozhuo Biotech (Zhejiang) Co., Ltd., Tongxiang, Jiaxing 314500, China. [5]Geneis (Beijing) Co., Ltd., Beijing 100102, China. [6]Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. [7]Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [8]School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China. [9]State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China. [10]Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing 100083, China. [11]Department of Mechanical Engineering, City University of Hong Kong, Hong Kong 999077, China. [12]Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China. [13]Center of Peony, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Flower Crops (North China), Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs, Beijing 100081, China. [14]Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. [15]Advanced Technology Institute, University of Surrey, Guildford, Surrey, GU2 7XH, UK. [16]National Physical Laboratory, Teddington, Middlesex TW11 0LW, UK. [17]Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [18]West China School of Basic Medical Sciences &amp [19]Forensic Medicine, Sichuan University, Chengdu 610041, China. [19]Jinfeng Laboratory, Chongqing 401329, China. [20]Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, China.

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In recent years, more and more single-cell technologies have been developed. A vast amount of single-cell omics data has been generated by large projects, such as the Human Cell Atlas, the Mouse Cell Atlas, the Mouse RNA Atlas, the Mouse ATAC Atlas, and the Plant Cell Atlas. Based on these single-cell big data, thousands of bioinformatics algorithms for quality control, clustering, cell-type annotation, developmental inference, cell-cell transition, cell-cell interaction, and spatial analysis are developed. With powerful experimental single-cell technology and state-of-the-art big data analysis methods based on artificial intelligence, the molecular landscape at the single-cell level can be revealed. With spatial transcriptomics and single-cell multi-omics, even the spatial dynamic multi-level regulatory mechanisms can be deciphered. Such single-cell technologies have many successful applications in oncology, assisted reproduction, embryonic development, and plant breeding. We not only review the experimental and bioinformatics methods for single-cell research, but also discuss their applications in various fields and forecast the future directions for single-cell technologies. We believe that spatial transcriptomics and single-cell multi-omics will become the next booming business for mechanism research and commercial industry.© 2022 The Authors.

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大类 | 1 区综合性期刊

小类 | 1 区综合性期刊

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第一作者机构： [1]Biomedical Pioneering Innovation Centre (BIOPIC), Peking University, Beijing 100871, China.

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通讯机构： [15]Advanced Technology Institute, University of Surrey, Guildford, Surrey, GU2 7XH, UK. [16]National Physical Laboratory, Teddington, Middlesex TW11 0LW, UK. [18]West China School of Basic Medical Sciences &amp [19]Forensic Medicine, Sichuan University, Chengdu 610041, China. [19]Jinfeng Laboratory, Chongqing 401329, China.

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