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Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma

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机构： [1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China [2]Department of Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan [4]Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China

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Immune checkpoint (IC) therapy has led to a breakthrough in cancer treatment. However, the interaction of ICs is controversial in glioma. We detected features of ICs using transcriptome data and a multicolor immunofluorescence assay. We discovered that B7-H3 increased with grade and age and predicted worse overall survival (OS) at the transcriptional and proteomic levels. VISTA and PD-L1 were associated with OS and grade at the RNA level. At the protein level, VISTA was primarily expressed in tumor cells and TAMs. B7-H3 and VISTA were positively correlated with PD-L1. There was a strong correlation between PD-L1 and CD3 and between VISTA and IBA-1. PD-L1 was coexpressed with T cells. VISTA was coexpressed with TAMs. In T cells, we found a strong correlation in ICs, which worsened in TAMs and tumor cells. In conclusion, B7-H3 is a vital prognostic target for immunotherapy. We provided a potential mechanism for the immunosuppressive microenvironment in glioma.Copyright © 2022. Published by Elsevier Inc.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区免疫学

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大类 | 3 区医学

小类 | 3 区免疫学

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第一作者机构： [1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China

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