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Decreased tubulin-binding cofactor B was involved in the formation disorder of nascent astrocyte processes by regulating microtubule plus-end growth through binding with end-binding proteins 1 and 3 after chronic alcohol exposure

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收录情况： ◇ SCIE

作者：
Zheng Yin[1,2] * ; Yang Mei[1] * ; Chen Xiaoqiao[1] * ; Zhang Gaoli[3] ; Wan Shanshan[4] ; Zhang Bingqiu[1] ; Huo Jiechao[5] ; Liu Hui[1] ;
机构： [1]Institute of Neuroscience, Chongqing Medical University, Chongqing, China, [2]Department of Basic Medicine, Chongqing College of Traditional Chinese Medicine, Chongqing, China, [3]Institute for Viral Hepatitis, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China, [4]Department of Blood Transfusion, Sichuan Cancer Hospital and Institute, Chengdu, China, [5]Fujian Province University Engineering Research Center of Mindong She Medicine, Medical College, Ningde Normal University, Ningde, China
出处：
DOI： 10.3389/fncel.2022.989945
ISSN：

关键词： end binding proteins ERK1/2 signaling pathway fetal alcohol syndrome microtubules tubulin-binding cofactor B

摘要：
Fetal alcohol syndrome (FAS) is a neurological disease caused by excessive drinking during pregnancy and characterized by congenital abnormalities in the structure and function of the fetal brain. This study was proposed to provide new insights into the pathogenesis of FAS by revealing the possible mechanisms of alcohol-induced astrocyte injury. First, a chronic alcohol exposure model of astrocytes was established, and the formation disorder was found in astrocyte processes where tubulin-binding cofactor B (TBCB) was decreased or lost, accompanied by disorganized microtubules (MT). Second, to understand the relationship between TBCB reduction and the formation disorder of astrocyte processes, TBCB was silenced or overexpressed. It caused astrocyte processes to retract or lose after silencing, while the processes increased with expending basal part and obtuse tips after overexpressing. It confirmed that TBCB was one of the critical factors for the formation of astrocyte processes through regulating MT plus-end and provided a new view on the pathogenesis of FAS. Third, to explore the mechanism of TBCB regulating MT plus-ends, we first proved end-binding proteins 1 and 3 (EB1/3) were bound at MT plus-ends in astrocytes. Then, through interference experiments, we found that both EB1 and EB3, which formed in heterodimers, were necessary to mediate TBCB binding to MT plus-ends and thus regulated the formation of astrocyte processes. Finally, the regulatory mechanism was studied and the ERK1/2 signaling pathway was found as one of the main pathways regulating the expression of TBCB in astrocytes after alcohol injury.Copyright © 2022 Zheng, Yang, Chen, Zhang, Wan, Zhang, Huo and Liu.

基金：
National Natural Science Foundation of China (81971230, 81500978, 81671312, and 81000566) and the Natural Science Foundation Project of Chong Qing (cstc2016jcyjA0229, cstc2017jcyjAX0414, cstc2015jcyja10018, and cstc2011jjA10093) and the Foundation of Chongqing Municipal Education Commission (KJ1600213).
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外文
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出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
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出版当年[2022]版：
Q1 NEUROSCIENCES
最新[2023]版：
Q2 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Institute of Neuroscience, Chongqing Medical University, Chongqing, China, [2]Department of Basic Medicine, Chongqing College of Traditional Chinese Medicine, Chongqing, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zheng Yin,Yang Mei,Chen Xiaoqiao,et al.Decreased tubulin-binding cofactor B was involved in the formation disorder of nascent astrocyte processes by regulating microtubule plus-end growth through binding with end-binding proteins 1 and 3 after chronic alcohol exposure[J].FRONTIERS IN CELLULAR NEUROSCIENCE.2022,16:doi:10.3389/fncel.2022.989945.
APA：
Zheng Yin,Yang Mei,Chen Xiaoqiao,Zhang Gaoli,Wan Shanshan...&Liu Hui.(2022).Decreased tubulin-binding cofactor B was involved in the formation disorder of nascent astrocyte processes by regulating microtubule plus-end growth through binding with end-binding proteins 1 and 3 after chronic alcohol exposure.FRONTIERS IN CELLULAR NEUROSCIENCE,16,
MLA：
Zheng Yin,et al."Decreased tubulin-binding cofactor B was involved in the formation disorder of nascent astrocyte processes by regulating microtubule plus-end growth through binding with end-binding proteins 1 and 3 after chronic alcohol exposure".FRONTIERS IN CELLULAR NEUROSCIENCE 16.(2022)

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