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A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma

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收录情况： ◇ 自然指数

作者：
Zhang Chao[1] ; Shen Hongru[2] ; Yang Tielong[1] ; Li Ting[1] ; Liu Xinyue[1] ; Wang Jin[1,3] ; Liao Zhichao[1] ; Wei Junqiang[1] ; Lu Jia[1] ; Liu Haotian[1] ; Xiang Lijie[1] ; Yang Yichen[2] ; Yang Meng[2] ; Wang Duan[4] ; Li Yang[2] ; Xing Ruwei[1] ; Teng Sheng[1] ; Zhao Jun[1] ; Yang Yun[1] ; Zhao Gang[5] ; Chen Kexin[6] ; Li Xiangchun[2] ; Yang Jilong[1] ;
机构： [1]Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory ofCancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute andHospital, Tianjin Medical University, 300060 Tianjin, China [2]Tianjin Cancer Institute, Tianjin’s Clinical Research Center for Cancer, National Clinical ResearchCenter for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, TianjinMedical University Cancer Institute and Hospital, Tianjin Medical University, 300060 Tianjin, China [3]Tianjin Academy of Traditional Chinese MedicineAffiliated hospital, 300120 Tianjin, China [4]Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu610041 Sichuan Province, China [5]Department of Pathology, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, KeyLaboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University CancerInstitute and Hospital, Tianjin Medical University, 300060 Tianjin, China [6]Department of Epidemiology and Biostatistics, Key Laboratory of Molecular CancerEpidemiology of Tianjin, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, National ClinicalResearch Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China
出处：
DOI： 10.1038/s41467-022-34877-3

摘要：
Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 acral and 3 cutaneous melanoma samples to investigate tumor heterogeneity and immune environment. We define 5 orthogonal functional cell clusters that are involved in TGF-beta signaling, Type I interferon, Wnt signaling, Cell cycle, and Cholesterol efflux signaling. Signatures of enriched TGF-beta, Type I interferon, and cholesterol efflux signaling are significantly associated with good prognosis of melanoma. Compared with cutaneous melanoma, acral melanoma samples have significantly severe immunosuppressive state including depletion of cytotoxic CD8+ T cells, enrichment of Treg cells, and exhausted CD8+ T cells. PD1 and TIM-3 have higher expression in the exhaustive CD8+ T cells of acral melanoma. Key findings are verified in two independent validation sets. This study contributes to our better understanding of acral melanoma.© 2022. The Author(s).

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出版当年[2022]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
第一作者：
第一作者机构： [1]Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory ofCancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute andHospital, Tianjin Medical University, 300060 Tianjin, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Chao,Shen Hongru,Yang Tielong,et al.A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma[J].Nature communications.2022,13(1):7250.doi:10.1038/s41467-022-34877-3.
APA：
Zhang Chao,Shen Hongru,Yang Tielong,Li Ting,Liu Xinyue...&Yang Jilong.(2022).A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma.Nature communications,13,(1)
MLA：
Zhang Chao,et al."A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma".Nature communications 13..1(2022):7250

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