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The Long-Term Outcome of Laparoscopic Resection for Perihilar Cholangiocarcinoma Compared with the Open Approach: A Real-World Multicentric Analysis

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WOS体系：
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收录情况： ◇ SCIE

作者：
Qin Tingting[1] ; Wang Min[1] ; Zhang Hang[1] ; Li Jingdong[2] ; Deng Xiaxing[3] ; Zhang Yuhua[4] ; Zhao Wenxing[5] ; Fan Ying[6] ; Li Dewei[7] ; Chen Xuemin[8] ; Feng Yechen[1] ; Zhu Siwei[9] ; Xing Zhongqiang[10] ; Yu Guangsheng[11] ; Xu Jian[2] ; Xie Junjie[3] ; Dou Changwei[4] ; Ma Hongqin[5] ; Liu Gangshan[6] ; Shao Yue[7] ; Chen Weibo[8] ; Xu Simiao[12] ; Liu Jun[11] ; Liu Jianhua[10] ; Yin Xinmin[9] ; Qin Renyi[1] ;
机构： [1]Department of Biliary–Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University ofScience and Technology, Wuhan, Hubei, China [2]Department of Hepatobiliary Surgery, Affiliated Hospital of NorthSichuan Medical College, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute of North Sichuan MedicalCollege, Nanchong, China [3]Department of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai,China [4]Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital,People’s Hospital of Hangzhou Medical College, Hangzhou, China [5]Department of General Surgery, The AffiliatedHospital of Xuzhou Medical University Xuzhou, Jiangsu, China [6]Department of the Second General Surgery, Sheng JingHospital of China Medical University, Liaoning, China [7]Department of Hepatobiliary Surgery, The First AffiliatedHospital of Chongqing Medical University, Chongqing, China [8]Department of Hepatopancreatobiliary Surgery, The ThirdAffiliated Hospital of Soochow University, Suzhou, China [9]Department of Hepatobiliary Surgery, Hunan ProvincialPeople’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China [10]Department ofHepato-Pancreato-Biliary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China [11]Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, ShandongProvincial Hospital Affiliated to Shandong University, Jinan, Shangdong, China [12]Department of Endocrinology,Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1245/s10434-022-12647-1
ISSN：

摘要：
The aim of this study was to compare the short- and long-term outcomes of laparoscopic surgery (LS) and open surgery (OP) for perihilar cholangiocarcinoma (PHC) using a large real-world dataset in China.Data of patients with PHC who underwent LS and OP from January 2013 to October 2018, across 10 centers in China, were extracted from medical records. A comparative analysis was performed before and after propensity score matching (PSM) in the LS and OP groups and within the study subgroups. The Cox proportional hazards mixed-effects model was applied to estimate the risk factors for mortality, with center and year of operation as random effects.A total of 467 patients with PHC were included, of whom 161 underwent LS and 306 underwent OP. Postoperative morbidity, such as hemorrhage, biliary fistula, abdominal abscess, and hepatic insufficiency, was similar between the LS and OP groups. The median overall survival (OS) was longer in the LS group than in the OP group (NA vs. 22 months; hazard ratio [HR] 1.19, 95% confidence interval [CI] 1.02-1.39, p = 0.024). Among the matched datasets, OS was comparable between the LS and OP groups (NA vs. 35 months; HR 0.99, 95% CI 0.77-1.26, p = 0.915). The mixed-effect model identified that the surgical method was not associated with long-term outcomes and that LS and OP provided similar oncological outcomes.Considering the comparable long-term prognosis and short-term outcomes of LS and OP, LS could be a technically feasible surgical method for PHC patients with all Bismuth-Corlett types of PHC.© 2022. The Author(s).

基金：
the National Natural Science Foundation of China (81772950 to RYQ, 81773160 to MW, 81702792 to SMX), Hubei Natural Science Foundation (2017CFB467) to MW, Tongji Hospital Clinical Research Flagship Program (2019CR203) to RYQ, and Tongji Hospital Science Fund for Distinguished Young Scholars (2017) to MW, as well as the National Key Research and Development Program of China (2019YFC1315905).

基金编号： 81772950 81773160 81702792 2017CFB467 2019CR203 2019YFC1315905

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 外科 3 区 肿瘤学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 外科 3 区 肿瘤学
JCR分区：
出版当年[2023]版：
Q1 SURGERY Q2 ONCOLOGY
最新[2023]版：
Q1 SURGERY Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Biliary–Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University ofScience and Technology, Wuhan, Hubei, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Qin Tingting,Wang Min,Zhang Hang,et al.The Long-Term Outcome of Laparoscopic Resection for Perihilar Cholangiocarcinoma Compared with the Open Approach: A Real-World Multicentric Analysis[J].ANNALS OF SURGICAL ONCOLOGY.2023,30(3):1366-1378.doi:10.1245/s10434-022-12647-1.
APA：
Qin Tingting,Wang Min,Zhang Hang,Li Jingdong,Deng Xiaxing...&Qin Renyi.(2023).The Long-Term Outcome of Laparoscopic Resection for Perihilar Cholangiocarcinoma Compared with the Open Approach: A Real-World Multicentric Analysis.ANNALS OF SURGICAL ONCOLOGY,30,(3)
MLA：
Qin Tingting,et al."The Long-Term Outcome of Laparoscopic Resection for Perihilar Cholangiocarcinoma Compared with the Open Approach: A Real-World Multicentric Analysis".ANNALS OF SURGICAL ONCOLOGY 30..3(2023):1366-1378

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