机构：[1]Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao266073, China.[2]Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao266021, China.[3]Department of Pharmacy, Neihuang Maternal and Child Health Hospital, Anyang456300, China.[4]National Engineering Research Center for Biomaterials, Sichuan University, Chengdu610064, China.[5]Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu610041, China.四川大学华西医院[6]College of Marine Life Science, Ocean University of China, Qingdao266003, China.[7]School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Provincial Institute of Xianwen Wang, Translational Medicine, Anhui Medical University, Hefei230032, China.
Poor antitumor drug penetration into tumor tissues is a global challenge in clinical cancer treatment. Here, we reported a smart multistage "Trojan Horse"-inspired bovine serum albumin (BSA)-coated liposome (HBM), including the mimics of capsid and secondary BSA-coated polymeric nanoparticles (NPs) for enhancing tumor penetration and antitumor efficacy. These drug-loaded polymeric NPs possess a capsid-like component, a well-distributed nanostructure (size: 190.1 ± 4.98 nm, PDI: 0.259), and an excellent drug loading content (15.85 ± 1.36%). Meaningfully, after the smart multistage BSA-coated liposome targeted the tumor tissue, the mimics of capsid were "taken off" under the condition of tumor-specific enzymes, releasing "Heart" BSA-modified secondary NPs to increase the ability to penetrate tumor cells for enhancing antitumor efficacy. As expected, the HBM efficiently achieves high drug penetration into PAN02 tumor cells. Moreover, compared to free DOX and HM (HBM without BSA) NPs, DOX/HBM NPs exhibited the strongest tumor penetration and the highest cytotoxicity against PAN02 tumor cells both in vitro (IC50 = 0.141 μg/mL) and in vivo. This smart multistage "Trojan Horse"-inspired BSA-coated liposome should provide a new hathpace for further development of polymeric NPs in clinical treatment.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区化学
小类|1 区有机化学1 区高分子科学2 区生化与分子生物学
最新[2023]版：
大类|2 区化学
小类|1 区有机化学1 区高分子科学2 区生化与分子生物学
第一作者：
第一作者机构：[1]Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao266073, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yan Jianqin,Shan Chan,Liang Caili,et al.Smart Multistage "Trojan Horse"-Inspired Bovine Serum Albumin-Coated Liposomes for Enhancing Tumor Penetration and Antitumor Efficacy[J].Biomacromolecules.2022,doi:10.1021/acs.biomac.2c00984.
APA：
Yan Jianqin,Shan Chan,Liang Caili,Han Jinting,He Bin...&Liang Yan.(2022).Smart Multistage "Trojan Horse"-Inspired Bovine Serum Albumin-Coated Liposomes for Enhancing Tumor Penetration and Antitumor Efficacy.Biomacromolecules,,
MLA：
Yan Jianqin,et al."Smart Multistage "Trojan Horse"-Inspired Bovine Serum Albumin-Coated Liposomes for Enhancing Tumor Penetration and Antitumor Efficacy".Biomacromolecules .(2022)
化学