机构：[1]State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.四川大学华西医院[2]Department of Dermatology, the Second People's Hospital of Neijiang, 641000, Neijiang, Sichuan, China.[3]Department of Cosmetic Dermatology, the First People's Hospital of Neijiang, 641000, Neijiang, Sichuan, China.[4]Department of Orthopedics, Orthopedics Research Institute, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.四川大学华西医院
This study aimed to explore the expression profile of interferon regulatory factor (IRF) genes in skin cutaneous melanoma (SKCM), their association with CD8+ T cell infiltration, and the potential regulatory network in melanoma and non-melanoma cells.Bioinformatic analysis was conducted using the SKCM subset of The Cancer Genome Atlas (TCGA) Pan-Cancer, Genotype-Tissue Expression Project (GTEx), and single-cell RNA-seq data from the Human Protein Atlas and Jerby-Arnon et al. 2018's dataset.IRF1 expression is robustly associated with moderate to strong CD8+ T cell infiltration in the tumor microenvironment. It is ubiquitously expressed in tumor and non-tumor cells in melanoma. Melanoma tumor cells and macrophages had 16/36 and 9/27 cell-specific IRF1-correlated genes, respectively. The methylation of four CpG sites (cg00255919, cg21138405, cg15375424, and cg27587780) within the IRF1 gene locus showed moderate to strong negative correlations with IRF1 expression.IRF1 expression might serve as a biomarker indicating CD8+ T cell infiltration in skin melanoma. It might exert different regulatory effects in melanoma and non-melanoma cells in the tumor microenvironment. Cg00255919, cg21138405, cg15375424, and cg27587780 are four critical CpG sites that might modulate the transcription of IRF1.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|3 区医学
小类|3 区免疫学
最新[2023]版：
大类|3 区医学
小类|3 区免疫学
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Shijie,Lu Chunli,Liu Gan,et al.IRF1 expression might be a biomarker of CD8+ T cell infiltration in cutaneous melanoma[J].Expert review of clinical immunology.2022,doi:10.1080/1744666X.2022.2141228.
APA：
Zhou Shijie,Lu Chunli,Liu Gan,Hu Qinsheng&Yang Jinliang.(2022).IRF1 expression might be a biomarker of CD8+ T cell infiltration in cutaneous melanoma.Expert review of clinical immunology,,
MLA：
Zhou Shijie,et al."IRF1 expression might be a biomarker of CD8+ T cell infiltration in cutaneous melanoma".Expert review of clinical immunology .(2022)
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