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GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair

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机构： [1]State Key Laboratory of Bioelectronics, Department of Otolaryngology Headand Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology,Advanced Institute for Life and Health, Jiangsu Province High Tech Key Laboratoryfor Bio-Medical Research, Southeast University, Nanjing 210096, China [2]The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518033,China [3]Department of Otolaryngology Head and Neck Surgery, AffiliatedDrum Tower Hospital of Nanjing University Medical School, Nanjing 210008,China [4]Department of Otolaryngology Head and Neck Surgery, SichuanProvincial People’s Hospital, University of Electronic Science and Technologyof China, Chengdu 610072, China [5]Co‑Innovation Center of Neuroregeneration,Nantong University, Nantong 226001, China [6]Institute for Stem Celland Regeneration, Chinese Academy of Science, Beijing 100086, China [7]Department of Anesthesiology, Sun Yat-Sen University Cancer Center, StateKey Laboratory of Oncology in Southern China, Collaborative Innovationfor Cancer Medicine, Guangzhou 510060, Guangdong, China [8]Beijing KeyLaboratory of Neural Regeneration and Repair, Capital Medical University, Beijing100069, China [9]Chien‑Shiung Wu College, Southeast university, Nanjing,China

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Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons and regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity and internal-facing longitudinal grooves and explore its function in SCI repair. It is found that the resultant grooved GelMA-MXene hydrogel could effectively promote the neural stem cells (NSCs) adhesion, directed proliferation and differentiation in vitro. Additionally, when the GelMA-MXene conduit loaded with NSCs (GMN) is implanted into the injured spinal cord site, effective repair capability for the complete transection of SCI was demonstrated. The GMN group shows remarkable nerve recovery and significantly higher BBB scores in comparison to the other groups. Therefore, GMN with the microgroove structure and loaded with NSCs is a promising strategy in treating SCI.© 2022. The Author(s).

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出版当年[2022]版：

大类 | 1 区

工程技术

小类 | 1 区生物工程与应用微生物 2 区纳米科技

最新[2023]版：

大类 | 1 区

生物学

小类 | 1 区生物工程与应用微生物 2 区纳米科技

JCR分区：

出版当年[2022]版：

Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 NANOSCIENCE & NANOTECHNOLOGY

最新[2023]版：

Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 10.6 最新[2023版] 11.4 最新五年平均 10.2 出版当年[2022版] 11.5 出版当年五年平均 9.429 出版前一年[2021版] 10.6 出版后一年[2023版]

第一作者：

第一作者机构： [1]State Key Laboratory of Bioelectronics, Department of Otolaryngology Headand Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology,Advanced Institute for Life and Health, Jiangsu Province High Tech Key Laboratoryfor Bio-Medical Research, Southeast University, Nanjing 210096, China

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通讯作者：

通讯机构： [1]State Key Laboratory of Bioelectronics, Department of Otolaryngology Headand Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology,Advanced Institute for Life and Health, Jiangsu Province High Tech Key Laboratoryfor Bio-Medical Research, Southeast University, Nanjing 210096, China [3]Department of Otolaryngology Head and Neck Surgery, AffiliatedDrum Tower Hospital of Nanjing University Medical School, Nanjing 210008,China [4]Department of Otolaryngology Head and Neck Surgery, SichuanProvincial People’s Hospital, University of Electronic Science and Technologyof China, Chengdu 610072, China [5]Co‑Innovation Center of Neuroregeneration,Nantong University, Nantong 226001, China [6]Institute for Stem Celland Regeneration, Chinese Academy of Science, Beijing 100086, China [8]Beijing KeyLaboratory of Neural Regeneration and Repair, Capital Medical University, Beijing100069, China

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