机构：[1]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.[2]Tea Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu, Sichuan, China.
Pediatric adrenocortical carcinomas (ACC) are rare aggressive neoplasms with heterogeneous prognosis, and often produce a most lethal malignant tumor, whereas its aetiology is still unclear. The aim of the present study was to identify the factors responsible for the development of pediatric ACC, a better understanding of the disease, and investigate new molecular biomarkers and therapeutic targets. To identify the key genes and miRNAs linked to pediatric ACC, as well as their potential molecular mechanisms, the GSEGSE75415 and GSE169253 microarray datasets were analyzed. A total of 329 differentially produced genes (DEGs) and 187 differentially produced miRNAs (DEMs) were obtained after analyzing the GSEGSE75415 and GSE169253 datasets, respectively. Next, 3,359 genes were obtained by overlapping the target mRNAs of DEMs. Following protein-protein interaction network and Gene Ontology analysis, the ten nodes with the highest degrees were screened as hub genes. Among them, the highly expressed hub genes, MAPK1 and EP300, were associated with a worse overall survival. Additionally, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305 were strongly associated with poorer survival. We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors. The roles of these hub genes in adrenocortical tumors may provide novel insight to improve the diagnosis and treatment of patients with pediatric ACC.2022, International Research and Cooperation Association for Bio & Socio - Sciences Advancement.
基金：
the National Natural Science Foundation of China [No. 81973647] and the Xinglin scholar discipline promotion talent program of Chengdu University of traditional Chinese medicine [No. BSH2021018].
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构：[1]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.[*1]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 shi-er-qiao Road, Chengdu, Sichuan 610072, China
推荐引用方式(GB/T 7714)：
Fang Chunyan,Ye Yulong,Wang Fangyue,et al.Identification of potential core genes and miRNAs in pediatric ACC via bioinformatics analysis[J].Intractable & rare diseases research.2022,11(3):133-142.doi:10.5582/irdr.2022.01077.
APA：
Fang Chunyan,Ye Yulong,Wang Fangyue,Shen Yifeng&You Yaodong.(2022).Identification of potential core genes and miRNAs in pediatric ACC via bioinformatics analysis.Intractable & rare diseases research,11,(3)
MLA：
Fang Chunyan,et al."Identification of potential core genes and miRNAs in pediatric ACC via bioinformatics analysis".Intractable & rare diseases research 11..3(2022):133-142
