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Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy

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机构： [1]National Engineering Research Center for Biomaterials, Sichuan University Chengdu 610064 P. R. China [2]Department of Pharmacy, The Second People's Hospital of Chengdu Chengdu 610017 P. R. China. [3]Institute of Organic Chemistry, Johannes Gutenberg-University Mainz Duesbergweg 10-14 55099 Mainz Germany. [4]College of Materials Science and Engineering, Nanjing Tech University 30 South Puzhu Road Nanjing 211816 P. R. China

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An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.This journal is © The Royal Society of Chemistry.

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大类 | 3 区材料科学

小类 | 3 区化学：综合 4 区材料科学：综合 4 区纳米科技

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第一作者机构： [1]National Engineering Research Center for Biomaterials, Sichuan University Chengdu 610064 P. R. China [2]Department of Pharmacy, The Second People's Hospital of Chengdu Chengdu 610017 P. R. China.

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