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Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications

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机构： [1]Orthopedic Research Institute, Department of Orthopedics, West ChinaHospital, Sichuan University, Chengdu, China [2]West China Hospital, WestChina School of Medicine, Sichuan University, Chengdu, China [3]SarcomaBiology Laboratory, Department of Orthopaedics, Sylvester ComprehensiveCancer Center, and the University of Miami Miller School of Medicine, Miami,FL 33136, USA

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关键词： Exosomes Tumor microenvironment Sarcoma Communication Clinical application

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The current diagnosis and treatment of sarcoma continue to show limited timeliness and efficacy. In order to enable the early detection and management of sarcoma, increasing attentions have been given to the tumor microenvironment (TME). TME is a dynamic network composed of multiple cells, extracellular matrix, vasculature, and exosomes. Exosomes are nano-sized extracellular vesicles derived from various cells in the TME. The major function of exosomes is to promote cancer progress and metastasis through mediating bidirectional cellular communications between sarcoma cells and TME cells. Due to the content specificity, cell tropism, and bioavailability, exosomes have been regarded as promising diagnostic and prognostic biomarkers, and therapeutic vehicles for sarcoma. This review summarizes recent studies on the roles of exosomes in TME of sarcoma, and explores the emerging clinical applications.© 2022. The Author(s).

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出版当年[2022]版：

大类 | 1 区

工程技术

小类 | 1 区生物工程与应用微生物 2 区纳米科技

最新[2023]版：

大类 | 1 区

生物学

小类 | 1 区生物工程与应用微生物 2 区纳米科技

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第一作者机构： [2]West China Hospital, WestChina School of Medicine, Sichuan University, Chengdu, China

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