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Cellular crosstalk during liver regeneration: unity in diversity

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资源类型：
Pubmed体系：
作者：
Shu Wenzhi[1,2,4,6,7] * ; Yang Mengfan[1,2,4,6] * ; Yang Jiayin[3] ; Lin Shengda[1,5] ; Wei Xuyong[1,2,4,6] ; Xu Xiao[1,2,4,6] ;
机构： [1]Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. [2]Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China. [3]Department of Liver Surgery and Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China. [4]NHC Key Laboratory of Combined Multi- Organ Transplantation, Hangzhou 310003, China. [5]Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou 310058, Zhejiang, China. [6]Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, China. [7]Program in Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China.
出处：
DOI： 10.1186/s12964-022-00918-z

关键词： Liver regeneration Hepatocytes Non-parenchymal cells Liver progenitor cells Cellular crosstalk

摘要：
The liver is unique in its ability to regenerate from a wide range of injuries and diseases. Liver regeneration centers around hepatocyte proliferation and requires the coordinated actions of nonparenchymal cells, including biliary epithelial cells, liver sinusoidal endothelial cells, hepatic stellate cells and kupffer cells. Interactions among various hepatocyte and nonparenchymal cells populations constitute a sophisticated regulatory network that restores liver mass and function. In addition, there are two different ways of liver regeneration, self-replication of liver epithelial cells and transdifferentiation between liver epithelial cells. The interactions among cell populations and regenerative microenvironment in the two modes are distinct. Herein, we first review recent advances in the interactions between hepatocytes and surrounding cells and among nonparenchymal cells in the context of liver epithelial cell self-replication. Next, we discuss the crosstalk of several cell types in the context of liver epithelial transdifferentiation, which is also crucial for liver regeneration. Video abstract.© 2022. The Author(s).

基金：
This work was supported by the National Key Research and Development Program of China (No.2021YFA1100502, No.2021YFA1100504); Key Program, National Natural Science Foundation of China (No. 81930016); Key Research & Development Plan of Zhejiang Province (No. 2019C03050).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
第一作者：
第一作者机构： [1]Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. [2]Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China. [4]NHC Key Laboratory of Combined Multi- Organ Transplantation, Hangzhou 310003, China. [6]Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, China. [7]Program in Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China.
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. [2]Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China. [4]NHC Key Laboratory of Combined Multi- Organ Transplantation, Hangzhou 310003, China. [6]Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, China.
推荐引用方式(GB/T 7714)：
Shu Wenzhi,Yang Mengfan,Yang Jiayin,et al.Cellular crosstalk during liver regeneration: unity in diversity[J].Cell communication and signaling : CCS.2022,20(1):117.doi:10.1186/s12964-022-00918-z.
APA：
Shu Wenzhi,Yang Mengfan,Yang Jiayin,Lin Shengda,Wei Xuyong&Xu Xiao.(2022).Cellular crosstalk during liver regeneration: unity in diversity.Cell communication and signaling : CCS,20,(1)
MLA：
Shu Wenzhi,et al."Cellular crosstalk during liver regeneration: unity in diversity".Cell communication and signaling : CCS 20..1(2022):117

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