机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China[2]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China[3]Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China[4]Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China[5]Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China[6]Sichuan Lung Cancer Institute, Sichuan Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China四川大学华西医院[7]Center of Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
Little is known about trends in the lung cancer burden from the disease that can be attributed to occupational carcinogens in China.Data regarding the lung cancer burden that can be attributed to occupational carcinogens in China were extracted from the Global Burden of Disease (GBD) study in 2019. Joinpoint regression analysis and an age-period-cohort (APC) analysis were conducted to estimate the trend of lung cancer burden as a result of occupational carcinogens from 1990 to 2019. A Bayesian APC model was used to predict the disease burden until 2044.The average annual percentage changes of age-standardized summary exposure values (SEVs) of occupational lung carcinogens, as well as the age-standardized population attributable fraction (PAF) of lung cancer due to occupational carcinogens, were 0.5% (95% confidence interval (CI): 0.4-0.5%) and 0.1% (95% CI: 0-0.2%), respectively. In addition, both the joinpoint regression analysis and APC analysis demonstrated significantly increased trends of age-standardized lung cancer mortality (ASMR) and age-standardized disability-adjusted life years (ASDR) as a result of occupational carcinogens. Asbestos and silica accounted for the two most important occupational lung carcinogens in China. The absolute burden is expected to increase, mainly due to population aging and the age-specific rate of illness.The lung cancer burden that could be attributed to occupational carcinogens significantly increased from 1990 to 2019 in China, and the absolute burden will continue to increase in the next 25 years.
基金：
This work was supported by China Medical Board (CMB, grant number: 21-445), the
Cancer Foundation of China (grant number: CFC2020KYXM001 and CFC2020KYXM002 to Y.F.,
CFC2020KYXM003 to X.L. (Xuebing Li)). This work was also partly supported by the Tianjin
Natural Science Foundation (18JCYBJC92100 to X.L. (Xuebing Li)), the National Natural Science
Foundation of China (grant number 81971650 to Z.M.), and the Tianjin Key Medical Discipline
(Specialty) Construction Project (grant number: TJYXZDXK-061B).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区医学
小类|2 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China
共同第一作者：
通讯作者：
通讯机构：[2]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China[7]Center of Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Fan Yaguang,Jiang Yong,Li Xin,et al.Burden of Lung Cancer Attributable to Occupational Carcinogens from 1990 to 2019 and Projections until 2044 in China[J].Cancers.2022,14(16):doi:10.3390/cancers14163883.
APA：
Fan Yaguang,Jiang Yong,Li Xin,Li Xuebing,Li Yang...&Qiao Youlin.(2022).Burden of Lung Cancer Attributable to Occupational Carcinogens from 1990 to 2019 and Projections until 2044 in China.Cancers,14,(16)
MLA：
Fan Yaguang,et al."Burden of Lung Cancer Attributable to Occupational Carcinogens from 1990 to 2019 and Projections until 2044 in China".Cancers 14..16(2022)
医学