机构：[1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.[2]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China[3]Department of biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.四川大学华西医院[4]Shenzhen Research Institute of Sun Yat-sen University, Shenzhen 518107, China深圳医学信息中心中国医学科学院阜外医院深圳医院
Bioinspired and biosafety antioxidant nanoparticle assemblies from natural occurring molecules have been regarded as a class of effective therapeutic nanomaterials for addressing current inflammatory diseases such as acute kidney injury. In this study, a series of epicatechin-assembled nanoparticles have been developed via one-pot enzymatic polymerization of epicatechin. The prepared poly (epicatechin) (PEC) nanoparticles (NPs) showed excellent antioxidant capacity to scavenge multiple toxic free radicals, thus being able to effectively protect cells under oxidative stress conditions in vitro. Furthermore, in the renal ischemia/reperfusion model, blood renal function testing and renal tissue staining revealed a prominent therapeutic effect of PEC NPs. All these findings suggested that this class of bioinspired antioxidant nanoparticles provided a new therapeutic strategy for human ischemia/reperfusion-related diseases.
基金：
This work sincerely acknowledges the support from the National
Natural Science Foundation of China (52173132), and the Fundamental
Research Funds for Central Universities.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区工程技术
小类|3 区材料科学：生物材料
最新[2023]版：
大类|3 区医学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
共同第一作者：
通讯作者：
通讯机构：[1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.[4]Shenzhen Research Institute of Sun Yat-sen University, Shenzhen 518107, China
推荐引用方式(GB/T 7714)：
Zhang Jianhua,Xie Huixu,Wang Tianyou,et al.Epicatechin-assembled nanoparticles against renal ischemia/reperfusion injury[J].Journal of materials chemistry. B.2022,doi:10.1039/d2tb01301k.
APA：
Zhang Jianhua,Xie Huixu,Wang Tianyou,Zhang Hengjie,Yang Zhen...&Gu Zhipeng.(2022).Epicatechin-assembled nanoparticles against renal ischemia/reperfusion injury.Journal of materials chemistry. B,,
MLA：
Zhang Jianhua,et al."Epicatechin-assembled nanoparticles against renal ischemia/reperfusion injury".Journal of materials chemistry. B .(2022)
工程技术