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Prognostic potential of circulating tumor DNA detection at different time periods in resectable non-small cell lung cancer: Evidence from a meta-analysis

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机构： [1]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China [2]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China [3]Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, 250117, Shandong, China [4]Department of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China

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This study was undertaken to evaluate the prognostic significance of circulating tumour DNA (ctDNA) detection at different time periods in resectable non-small cell lung cancer (NSCLC). A comprehensive search strategy was conducted through the electronic platforms published up to June 2022. In total, 7 studies with 1138 patients were included. Patients with positive ctDNA have an increased risk of recurrence and mortality. The association between risk of recurrence and detectable ctDNA after surgery 3 days-2 weeks and 1-3 months was stronger than detected at 1 week before surgery. The predictive value of longitudinal detection ctDNA for recurrence and mortality was not stronger than at other time periods. In conclusion, ctDNA is a promising biomarker for predictive recurrence and survival in resectable NSCLC patients. The ctDNA detection after surgery 3 days-2 weeks with more reliably and feasible in identifying resectable NSCLC patients at high risk for recurrence.Copyright © 2022. Published by Elsevier B.V.

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出版当年[2022]版中科院分区表Review为是的期刊

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大类 | 2 区医学

小类 | 2 区血液学 2 区肿瘤学

最新[2023]版

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大类 | 2 区

医学

小类 | 2 区血液学 2 区肿瘤学

第一作者：

第一作者机构： [1]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China [2]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China [3]Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, 250117, Shandong, China

通讯作者：

通讯机构： [2]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China [3]Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, 250117, Shandong, China [*1]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China.

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