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Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers

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机构： [1]Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. [2]Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China. [3]Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. [4]Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. [5]Pharmacy Department, Zichuan District Hospital, Zichuan, Shandong 255100, China. [6]Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China. [7]School of Life Sciences, Tsinghua University, Beijing 100084, China. [8]Department of Rheumatology and Immunology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [9]Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China. [10]Cancer Center, Peking University Third Hospital, Beijing 100191, China. [11]State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

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Autoimmune diseases (ADs) are at a significantly higher risk of cancers with unclear mechanism. By searching GWAS catalog database and Medline, susceptible genes for five common ADs, including systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjögren syndrome, systemic sclerosis, and idiopathic inflammatory myopathies, were collected and then were overlapped with cancer driver genes. Single-cell transcriptome analysis was performed in the comparation between SLE and related cancer. We identified 45 carcinogenic autoimmune disease risk (CAD) genes, which were mainly enriched in T cell signaling pathway and B cell signaling pathway. Integrated single-cell analysis revealed immune cell signaling was significantly downregulated in renal cancer compared with SLE, while stemness signature was significantly enriched in both renal cancer or lymphoma and SLE in specific subpopulations. Drugs targeting CAD genes were shared between ADs and cancer. Our study highlights the common and specific features between ADs and related cancers, and sheds light on a new discovery of treatments.© 2022 The Authors.

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大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

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大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

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Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 4.6 最新[2023版] 5 最新五年平均 5.8 出版当年[2022版] 5.8 出版当年五年平均 6.107 出版前一年[2021版] 4.6 出版后一年[2023版]

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第一作者机构： [1]Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.

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通讯机构： [9]Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China. [10]Cancer Center, Peking University Third Hospital, Beijing 100191, China.

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