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Targeting the transcriptional activity of STAT3 by a novel fusion protein

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机构： [1]National Clinical Research Center for Geriatrics and Laboratory of Human Diseaseand Immunotherapies, West China Hospital, Sichuan University, SichuanProvince, Chengdu 610041, China [2]Research Institute of Inflammationand Immunology (RIII), Frontiers Science Center for Disease‑related MolecularNetwork, West China Hospital, Sichuan University, Chengdu, China [3]Rare DiseasesCenter, West China Hospital, Sichuan University, Chengdu 610041, China

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摘要：

The continuous activation of transcription factors drives many diseases, including tumors, autoimmune disease, neurodegenerative disease, and male infertility. Thus, Blocking the transcriptional activity of these proteins may inhibit disease progression. In this study, we developed a new method to specifically inhibit the activity of the transcription factor STAT3.Fusing the transcriptional inhibitory domain KRAB with STAT3 successfully blocked the transcription activity of STAT3 in cancer cells without affecting its function in the mitochondria and lysosomes.the expression of KRAB-STAT3 fusion protein inhibited the growth of tumor cells.The KRAB-STAT3 fusion protein provides a novel approach for drug development for the treatment of cancer or autoimmune diseases.© 2022. The Author(s).

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 2 区

医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]National Clinical Research Center for Geriatrics and Laboratory of Human Diseaseand Immunotherapies, West China Hospital, Sichuan University, SichuanProvince, Chengdu 610041, China [2]Research Institute of Inflammationand Immunology (RIII), Frontiers Science Center for Disease‑related MolecularNetwork, West China Hospital, Sichuan University, Chengdu, China

通讯作者：

通讯机构： [1]National Clinical Research Center for Geriatrics and Laboratory of Human Diseaseand Immunotherapies, West China Hospital, Sichuan University, SichuanProvince, Chengdu 610041, China [2]Research Institute of Inflammationand Immunology (RIII), Frontiers Science Center for Disease‑related MolecularNetwork, West China Hospital, Sichuan University, Chengdu, China [3]Rare DiseasesCenter, West China Hospital, Sichuan University, Chengdu 610041, China

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