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The Role and Mechanisms of Action of Natural Compounds in the Prevention and Treatment of Cancer and Cancer Metastasis.

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收录情况： ◇ SCIE

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机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, 999078 Macau, China. [2]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, 518020 Shenzhen, Guangdong, China. [3]Department of Intervention, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, 646000 Luzhou, Sichuan, China. [4]Education Evaluation and Faculty Development Center, Guangxi Medical University, 530021 Nanning, Guangxi, China. [5]Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China. [6]College of Pharmacy, Hangzhou Normal University, 310030 Hangzhou, Zhejiang, China. [7]Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, 310030 Hangzhou, Zhejiang, China. [8]Faculty of Health Sciences, University of Macau, Taipa, 999078 Macau, China. [9]Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, 510000 Guangzhou, Guangdong, China. [10]Zhuhai MUST Science and Technology Research Institute, 51900 Zhuhai, Guangdong, China.

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Cancer has emerged as one of the world's most concerning health problems. The progression and metastasis mechanisms of cancer are complex, including metabolic disorders, oxidative stress, inflammation, apoptosis, and intestinal microflora disorders. These pose significant challenges to our efforts to prevent and treat cancer and its metastasis. Natural drugs have a long history of use in the prevention and treatment of cancer. Many effective anti-tumor drugs, such as Paclitaxel, Vincristine, and Camptothecin, have been widely prescribed for the prevention and treatment of cancer. In recent years, a trend in the field of antitumor drug development has been to screen the active antitumor ingredients from natural drugs and conduct in-depth studies on the mechanisms of their antitumor activity. In this review, high-frequency keywords included in the literature of several common Chinese and English databases were analyzed. The results showed that five Chinese herbal medicines (Radix Salviae, Panax Ginseng C. A. Mey, Hedysarum Multijugum Maxim, Ganoderma, and Curcumaelongae Rhizoma) and three natural compounds (quercetin, luteolin, and kaempferol) were most commonly used for the prevention and treatment of cancer and cancer metastasis. The main mechanisms of action of these active compounds in tumor-related research were summarized. Finally, we found that four natural compounds (dihydrotanshinone, sclareol, isoimperatorin, and girinimbin) have recently attracted the most attention in the field of anti-cancer research. Our findings provide some inspiration for future research on natural compounds against tumors and new insights into the role and mechanisms of natural compounds in the prevention and treatment of cancer and cancer metastasis.© 2022 The Author(s). Published by IMR Press.

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出版当年[2022]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

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出版当年[2022]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3.3 最新[2023版] 3.6 最新五年平均 3.1 出版当年[2022版] 3.9 出版当年五年平均 3.115 出版前一年[2021版] 3.3 出版后一年[2023版]

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第一作者机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, 999078 Macau, China.

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通讯作者：

通讯机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, 999078 Macau, China. [6]College of Pharmacy, Hangzhou Normal University, 310030 Hangzhou, Zhejiang, China. [7]Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, 310030 Hangzhou, Zhejiang, China. [9]Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, 510000 Guangzhou, Guangdong, China. [10]Zhuhai MUST Science and Technology Research Institute, 51900 Zhuhai, Guangdong, China.

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