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Exosomes Participate in the Radiotherapy Resistance of Cancers.

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资源类型：
Pubmed体系：
作者：
He Dan[1,2] * ; Zhao Zhe[3] * ; Fu Bo[2] ; Li Xiaofei[2] ; Zhao Long[2,4] ; Chen Yongbin[5,6] ; Liu Lei[1] ; Liu Rui[7] ; Li Jingyi[2,4] ;
机构： [1]Department of Head and Neck Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R.China [2]The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, P.R.China [3]School of Laboratory Medicine,Chengdu Medical College, Chengdu, P.R.China [4]School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, P.R.China [5]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China [6]Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China [7]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, P.R. China
出处：
DOI： 10.1667/RADE-21-00115.1
ISSN：

摘要：
Radiotherapy is one of the main treatment modalities for cancer. However, some cancer patients will gradually develop resistance to radiotherapy, leading to tumor recurrence and metastasis. Radiation therapy usually promotes the secretion of exosomes from tumor cells and causes changes in their internal components. Accumulating evidence reveals that exosomes-mediated radiation-induced bystander effect (RIBE) is closely involved in radiotherapy resistance. In this article, we will discuss the relationship between exosomes and RIBE, highlight the effect of exosome components on resistance to radiation, and emphasize the role of exosome inclusion as a tumor biomarker for the prognosis of tumor treatment to develop new therapeutic approaches.©2022 by Radiation Research Society. All rights of reproduction in any form reserved.

基金：
This work was supported by grants from the Scientific Research Program for Young Talents of China National Nuclear Corporation (2020CNNC74), the Science & Technology Department of Sichuan Province (2019YJ0371; 2020YJ0371; 2020YFSY0009; 2021YJ0204), Health Commission of Sichuan Province (20PJ226), Sichuan Collaborative Innovation Center for elderly care and health (YLZBZ2024), Sichuan Medical Research youth innovation project (Q19034) and Suzhou University (KJS1962; GZK1202005).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 生物学 3 区 生物物理 3 区 核医学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 生物物理 3 区 生物学 4 区 核医学
第一作者：
第一作者机构： [1]Department of Head and Neck Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R.China [2]The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, P.R.China
共同第一作者：
通讯作者：
通讯机构： [2]The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, P.R.China [4]School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, P.R.China
推荐引用方式(GB/T 7714)：
He Dan,Zhao Zhe,Fu Bo,et al.Exosomes Participate in the Radiotherapy Resistance of Cancers.[J].Radiation Research.2022,197(5):559-565.doi:10.1667/RADE-21-00115.1.
APA：
He Dan,Zhao Zhe,Fu Bo,Li Xiaofei,Zhao Long...&Li Jingyi.(2022).Exosomes Participate in the Radiotherapy Resistance of Cancers..Radiation Research,197,(5)
MLA：
He Dan,et al."Exosomes Participate in the Radiotherapy Resistance of Cancers.".Radiation Research 197..5(2022):559-565

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