Circular RNAs (circRNAs) are widely present and participate in a variety of biological regulatory activities as a novel type of endogenous noncoding RNA molecule. With advances in RNA structure and function analysis, it was found that circRNAs are present in a myriad of life processes and longevity in model organisms such as mice, flies, and worms. Accumulating evidence indicates the involvement of circRNAs in regulation of age-related pathologies such as cancer, diabetes, cardiovascular disorders, and neurodegenerative disease, suggesting that circRNAs may have great potential implications in clinical and research fields. In this chapter, we review recent advances in circRNA functions and mechanisms and discuss their roles in aging and age-related diseases. It will provide insight into the regulatory roles of circRNAs in aging and age-related diseases.
基金：
This work was supported by the National Natural Science Foundation of
China (No. 31771338 and No. 31471998).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|3 区生物学4 区医学：研究与实验
最新[2023]版：
无
第一作者：
第一作者机构：[1]Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, China.
通讯作者：
通讯机构：[3]Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, China.
推荐引用方式(GB/T 7714)：
Yang Deying,Yang Katie,Yang Mingyao.Circular RNA in Aging and Age-Related Diseases.[J].Advances in experimental medicine and biology.2018,1086:17-35.doi:10.1007/978-981-13-1117-8_2.
APA：
Yang Deying,Yang Katie&Yang Mingyao.(2018).Circular RNA in Aging and Age-Related Diseases..Advances in experimental medicine and biology,1086,
MLA：
Yang Deying,et al."Circular RNA in Aging and Age-Related Diseases.".Advances in experimental medicine and biology 1086.(2018):17-35
